Dérégulations épigénétiques induites par la protéine fusion BRD4-NUT et caractérisation de la proteine NUT au cours de la spermatogenèse et dans les cancers

Doctoral thesis French OPEN
Reynoird , Nicolas;
(2010)
  • Publisher: HAL CCSD
  • Subject: acetylation | BRD4-NUT | epigenetic | [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] | epigenetique | chromatine | [ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] | chromatin | CBP/p300
    mesheuropmc: food and beverages | digestive, oral, and skin physiology

Nowadays, it is clear that cancer cannot be reduced only to genetic abberations, and that a new parameter has to be considered, epigenetic. During my thesis, I have characterized the fusion protein BRD4-NUT, which results of a t(15;19) translocation observed in NUT midl... View more
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