Heme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450

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Vinchi, Francesca; Ingoglia, Giada; Chiabrando, Deborah; Mercurio, Sonia; Turco, Emilia; Silengo, Lorenzo; Altruda, Fiorella; Tolosano, Emanuela;
  • Publisher: W.B. Saunders
  • Journal: Gastroenterology, volume 146, issue 5, pages 1,325-1,338 (issn: 0016-5085, eissn: 1528-0012)
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  • Identifiers: doi: 10.1053/j.gastro.2014.01.053, pmc: PMC4000440
  • Subject: ALAS, 5-aminolevulinic acid synthase | Fpn, ferroportin | Flvcr1 | Be(a)P, benzo(a)pyrene | Gastroenterology | CYP, cytochrome P450 | mRNA, messenger RNA | Flvcr | HO, heme oxygenase | FLVCR; CYP; ALAS1; HO-1 | Original Research | Full Report: Basic and Translational—Liver | CYP | HO-1 | ALAS1 | ALA, 5-aminolevulinic acid | FLVCR1a, feline leukemia virus subgroup C cellular receptor 1a

Background & Aims The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural products, hormones... View more
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