publication . Article . 2006

ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis

Pinto, Patrícia IS; Singh, Pratap B; Condeça, João B; Teodósio, Helena R; Power, Deborah M; Canário, Adelino VM;
Open Access English
  • Published: 01 Dec 2006 Journal: Reproductive Biology and Endocrinology, volume 4, pages 67-67 (issn: 1477-7827, eissn: 1477-7827, Copyright policy)
  • Publisher: BMC
Abstract
<p>Abstract</p> <p>Background</p> <p>ICI 182,780 (ICI) belongs to a new class of antiestrogens developed to be pure estrogen antagonists and, in addition to its therapeutic use, it has been used to knock-out estrogen and estrogen receptor (ER) actions in several mammalian species. In the present study, the effects and mechanism of action of ICI were investigated in the teleost fish, sea bream (Sparus auratus).</p> <p>Methods</p> <p>Three independent in vivo experiments were performed in which mature male tilapia (Oreochromis mossambicus) or sea bream received intra-peritoneal implants containing estradiol-17 beta (E2), ICI or a combination of both compounds. The...
Subjects
mesheuropmc: hormones, hormone substitutes, and hormone antagonists
free text keywords: RG1-991, Gynecology and obstetrics, QH471-489, Research, Reproduction
Related Organizations
Funded by
FCT| POCTI/CVT/39355/2001
Project
POCTI/CVT/39355/2001
The estrogen receptor in seabream (Sparus aurata) reproduction: diversity, expression, mechanisms and physiological actions
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 39355
  • Funding stream: POCI
48 references, page 1 of 4

Bjornstrom, L, Sjoberg, M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol. 2005; 19: 833-842 [PubMed] [DOI]

Smith, CL, O'Malley, BW. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev. 2004; 25: 45-71 [PubMed] [DOI]

Bardet, PL, Horard, B, Robinson-Rechavi, M, Laudet, V, Vanacker, JM. Characterization of oestrogen receptors in zebrafish (Danio rerio).. J Mol Endocrinol. 2002; 28: 153-163 [PubMed] [DOI]

Halm, S, Martinez-Rodriguez, G, Rodriguez, L, Prat, F, Mylonas, CC, Carrillo, M, Zanuy, S. Cloning, characterisation, and expression of three oestrogen receptors (ERa, ERb1 and ERb2) in the European sea bass, Dicentrarchus labrax. Mol Cell Endocrinol. 2004; 223: 63-75 [OpenAIRE] [PubMed] [DOI]

Pinto, PI, Passos, AL, Martins, RS, Power, DM, Canario, AV. Characterization of estrogen receptor bb in sea bream (Sparus auratus): phylogeny, ligand-binding, and comparative analysis of expression. Gen Comp Endocrinol. 2006; 145: 197-207 [PubMed] [DOI]

Thomas, P, Pang, Y, Filardo, EJ, Dong, J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.. Endocrinology. 2005; 146: 624-632 [PubMed] [DOI]

Pedram, A, Razandi, M, Levin, ER. Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol. 2006; 20: 1996-2009 [PubMed] [DOI]

Pike, AC, Brzozowski, AM, Hubbard, RE, Bonn, T, Thorsell, AG, Engstrom, O, Ljunggren, J, Gustafsson, JA, Carlquist, M. Structure of the ligand-binding domain of oestrogen receptor b in the presence of a partial agonist and a full antagonist.. EMBO J. 1999; 18: 4608-4618 [OpenAIRE] [PubMed] [DOI]

Frasor, J, Stossi, F, Danes, JM, Komm, B, Lyttle, CR, Katzenellenbogen, BS. Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer Cells. Cancer Res. 2004; 64: 1522-1533 [PubMed] [DOI]

Henke, BR, Heyer, D. Recent advances in estrogen receptor modulators. Curr Opin Drug Discov Devel. 2005; 8: 437-448 [PubMed]

Osborne, CK, Wakeling, A, Nicholson, RI. Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action. Br J Cancer. 2004; 90 Suppl 1 : S2-S6 [OpenAIRE] [PubMed] [DOI]

Morris, C, Wakeling, A. Fulvestrant ('Faslodex')-a new treatment option for patients progressing on prior endocrine therapy. Endocrine-related cancer. 2002; 9: 267-276 [PubMed] [DOI]

Lee, KH, Hess, RA, Bahr, JM, Lubahn, DB, Taylor, J, Bunick, D. Estrogen receptor a has a functional role in the mouse rete testis and efferent ductules. Biol Reprod. 2000; 63: 1873-1880 [PubMed] [DOI]

Matthews, J, Almlof, T, Kietz, S, Leers, J, Gustafsson, JA. Estrogen receptor-a regulates SOCS-3 expression in human breast cancer cells. Biochem Biophys Res Commun. 2005; 335: 168-174 [PubMed] [DOI]

Carlson, RW. The history and mechanism of action of fulvestrant.. Clin Breast Cancer. 2005; 6 Suppl 1: S5-S8 [PubMed]

48 references, page 1 of 4
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2006

ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis

Pinto, Patrícia IS; Singh, Pratap B; Condeça, João B; Teodósio, Helena R; Power, Deborah M; Canário, Adelino VM;