publication . Article . 2019

Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Aβ42 decline in non-demented elders

Kai-Xin Dou; Can Zhang; Chen-Chen Tan; Wei Xu; Jie-Qiong Li; Xi-Peng Cao; Lan Tan; Jin-Tai Yu; null Alzheimer�s Disease Neuroimaging Initiative (ADNI);
Open Access
  • Published: 01 Aug 2019 Journal: Aging, volume 11 (eissn: 1945-4589, Copyright policy)
  • Publisher: Impact Journals, LLC
Abstract
Brain amyloid deposition is an early pathological event in Alzheimer’s disease (AD), and abnormally low levels amyloid-β42 peptide (Aβ42) in cerebrospinal fluid (CSF) can be detected in preclinical AD. To identify the genetic determinants that regulate the rate of CSF Aβ42 decline among non-demented elders, we conducted a genome-wide association study involved 321 non-demented elders from Alzheimer’s Disease Neuroimaging Initiative (ADNI) 1/GO/2 cohorts restricted to non-Hispanic Caucasians. A novel genome-wide significant association of higher annualized percent decline of CSF Aβ42 in the gene CBFA2T3 (CBFA2/RUNX1 translocation partner 3; rs13333659-T; p = 2.24...
Subjects
free text keywords: Genome-wide association study, Cerebrospinal fluid, Chromosomal translocation, Locus (genetics), Pathological, Disease, Medicine, business.industry, business, Immunology, Cognitive decline, Neuroimaging, Research Paper, Alzheimer’s disease, amyloid, genetics, GWAS
Related Organizations
Funded by
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
Communities
Neuroinformatics
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