publication . Article . 2012

Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations

A. C. C. Freitas; N. C. A. Ximenes; J. S. Aguiar; S. C. Nascimento; T. U. L. Lins; L. R. Magalhães; L. C. B. B. Coelho; M. G. Carneiro-da-Cunha; T. Gonçalves-Silva; M. T. S. Correia;
Open Access English
  • Published: 01 May 2012 Journal: Evidence-Based Complementary and Alternative Medicine, volume 2,012 (issn: 1741-427X, eissn: 1741-4288, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
Abstract
Libidibia ferrea has been used in folk medicine throughout Brazil, and this study evaluated the biological activities of crude extract (CE) as well as a partially purified fraction (F80) obtained from its pods. Results from the MTT assay revealed that only F80 inhibited NCI-H292 cell growth; however, neither CE nor F80 reduced HEp-2 cell growth or sarcoma 180 tumor weight with the in vivo assay. Acute oral toxicity of the extract and fraction was evaluated following the steps of Guideline 423, using female mice; LD50 for both preparations was determined as 2,500 mg/kg body weight. CE and F80 promoted a reduction of the leukocyte number and nitrite level in infla...
Subjects
free text keywords: Other systems of medicine, Research Article, RZ201-999, Article Subject
44 references, page 1 of 3

Bragança, L. A. R.. Plantas Medicinais Antidiabéticas. 1996

Lorenzi, H.. Árvores Brasileiras Manual de Identificação e Cultivo de Plantas Arbóreas Nativas do Brasil. 2002

Balbach, A.. As Plantas que Curam. 1972

Hashimoto, G.. Illustrated Cyclopedia of Brazilian Medicinal Plants. 1996

Nakamura, E. L. S., Kurosaki, F., Arisawa, M., Mukainaka, T., Okuda, M., Tokuda, H., Nishino, H., Pastore, F.. Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds. Cancer Letters. 2002; 177 (2): 119-124

Gomes, M.. As Plantas da Saúde—Guia de Tratamentos Naturais. 2003

Nakamura, E. L. S., Kurosaki, F., Arisawa, M., Mukainaka, T., Takayasu, J., Okuda, M., Tokuda, H., Nishino, H., Pastore, F.. Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis. Journal of Ethnopharmacology. 2002; 81 (1): 135-137

Pereira, E. C., Nascimento, S. C., Lima, R. C., Silva, N. H., Oliveira, A. F. M., Bandeira, E., Boitard, M., Beriel, H., Vicente, C., Legaz, M. E.. Analysis of Usnea fasciat a crude extracts with antineoplastic activity. Tokai Journal of Experimental and Clinical Medicine. 1994; 19 (1-2): 47-52

Alley, M. C., Scudiero, D. A., Monks, A., Hursey Czerwinski, M. L. M. J., Fine, D. L., Abbott, B. J., Mayo, J. G., Shoemaker, R. H., Boyd, M. R.. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Research. 1988; 48 (3): 589-601

Slater, S. F., Sawter, R., Strauli, U.. Studies on succinate-tetrazolium reductase system—III. Points of coupling of different tetrazolium salts. Biochemical et Biophysica Acta. 1963; 77: 383-393

Hess, R., Pearse, A. G. E.. Pathways of reduced pyridine nucleotide oxidation in rat-brain homogenate demonstrated by a tetrazolium method. Biochimica et Biophysica Acta. 1963; 71: 285-294

Geran, R. I., Greenber, N. H., Macdonald, M. M., Schumacher, R. I., Abbott, B. J.. Protocols for screening chemical agents and natural-products against tumors and other biological systems. Cancer Chemotherapy Reports. 1972; 2 (3, part 3)

OECD-Organization for Economic Cooperation and Development, null. OECD Guideline for Testing of Chemicals. 2001

Gupta, M., Mazumder, U. K., Sambath Kumar, R., Gomathi, P., Rajeshwar, Y., Kakoti, B. B., Tamil Selven, V.. Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. Journal of Ethnopharmacology. 2005; 98 (3): 267-273

44 references, page 1 of 3
Abstract
Libidibia ferrea has been used in folk medicine throughout Brazil, and this study evaluated the biological activities of crude extract (CE) as well as a partially purified fraction (F80) obtained from its pods. Results from the MTT assay revealed that only F80 inhibited NCI-H292 cell growth; however, neither CE nor F80 reduced HEp-2 cell growth or sarcoma 180 tumor weight with the in vivo assay. Acute oral toxicity of the extract and fraction was evaluated following the steps of Guideline 423, using female mice; LD50 for both preparations was determined as 2,500 mg/kg body weight. CE and F80 promoted a reduction of the leukocyte number and nitrite level in infla...
Subjects
free text keywords: Other systems of medicine, Research Article, RZ201-999, Article Subject
44 references, page 1 of 3

Bragança, L. A. R.. Plantas Medicinais Antidiabéticas. 1996

Lorenzi, H.. Árvores Brasileiras Manual de Identificação e Cultivo de Plantas Arbóreas Nativas do Brasil. 2002

Balbach, A.. As Plantas que Curam. 1972

Hashimoto, G.. Illustrated Cyclopedia of Brazilian Medicinal Plants. 1996

Nakamura, E. L. S., Kurosaki, F., Arisawa, M., Mukainaka, T., Okuda, M., Tokuda, H., Nishino, H., Pastore, F.. Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds. Cancer Letters. 2002; 177 (2): 119-124

Gomes, M.. As Plantas da Saúde—Guia de Tratamentos Naturais. 2003

Nakamura, E. L. S., Kurosaki, F., Arisawa, M., Mukainaka, T., Takayasu, J., Okuda, M., Tokuda, H., Nishino, H., Pastore, F.. Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis. Journal of Ethnopharmacology. 2002; 81 (1): 135-137

Pereira, E. C., Nascimento, S. C., Lima, R. C., Silva, N. H., Oliveira, A. F. M., Bandeira, E., Boitard, M., Beriel, H., Vicente, C., Legaz, M. E.. Analysis of Usnea fasciat a crude extracts with antineoplastic activity. Tokai Journal of Experimental and Clinical Medicine. 1994; 19 (1-2): 47-52

Alley, M. C., Scudiero, D. A., Monks, A., Hursey Czerwinski, M. L. M. J., Fine, D. L., Abbott, B. J., Mayo, J. G., Shoemaker, R. H., Boyd, M. R.. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Research. 1988; 48 (3): 589-601

Slater, S. F., Sawter, R., Strauli, U.. Studies on succinate-tetrazolium reductase system—III. Points of coupling of different tetrazolium salts. Biochemical et Biophysica Acta. 1963; 77: 383-393

Hess, R., Pearse, A. G. E.. Pathways of reduced pyridine nucleotide oxidation in rat-brain homogenate demonstrated by a tetrazolium method. Biochimica et Biophysica Acta. 1963; 71: 285-294

Geran, R. I., Greenber, N. H., Macdonald, M. M., Schumacher, R. I., Abbott, B. J.. Protocols for screening chemical agents and natural-products against tumors and other biological systems. Cancer Chemotherapy Reports. 1972; 2 (3, part 3)

OECD-Organization for Economic Cooperation and Development, null. OECD Guideline for Testing of Chemicals. 2001

Gupta, M., Mazumder, U. K., Sambath Kumar, R., Gomathi, P., Rajeshwar, Y., Kakoti, B. B., Tamil Selven, V.. Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. Journal of Ethnopharmacology. 2005; 98 (3): 267-273

44 references, page 1 of 3
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publication . Article . 2012

Biological Activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod Preparations

A. C. C. Freitas; N. C. A. Ximenes; J. S. Aguiar; S. C. Nascimento; T. U. L. Lins; L. R. Magalhães; L. C. B. B. Coelho; M. G. Carneiro-da-Cunha; T. Gonçalves-Silva; M. T. S. Correia;