The small heat shock protein αA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis

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Deng , Mi; Chen , Pei-Chao; Xie , Sisi; Zhao , Junqiong; Gong , Lili; Liu , Jinping; Zhang , Lan; Sun , Shuming; Liu , Jiao; Ma , Haili; Batra , Surinder; Li , David Wan-Cheng;
  • Publisher: Elsevier BV
  • Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,volume 1,802,issue 7-8,pages621-631 (issn: 0925-4439)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.bbadis.2010.04.004
  • Subject: αA | Molecular Biology | Pancreatic Cancer | Pancreas | Small heat shock protein | Cell migration | Molecular Medicine | TGFβ | Smad2/3/5 | AP-1
    mesheuropmc: eye diseases | sense organs

International audience; The small heat shock protein αA-crystallin is a structural protein in the ocular lens. In addition, recent studies have also revealed that it is a molecular chaperone, an autokinase and a strong anti-apoptotic regulator. Besides its lenticular di... View more
  • References (7)

    Aguirre, A.J., Bardeesy, N., Sinha, M., LoNpez, L., Tuveson, D.A., Horner, J., Redston, M.S., and DePinho, R.A. 2003. Activated Kras and Ink4a/Arf A

    Genes & Dev.17(2003)3112-3126.

    Frequent alterations in the APC/ -catenin pathway and chromosome 11p. Am.

    J. Pathol. 159 (2001)161T9-1627.

    Bardeesy, N., Cheng, PK.-h., Berger, J.H., Chu, G.C., Pahler, J., Olson, P., Hezel, A.F., HornEer, J., Lauwers, G.Y., Hanahan, D., et al. 2006. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology Cofpancreas cancer. Genes & Dev. 20(2006) 3130-3146.

    Ijichi, H., CChytil, A., Gorska, A.E., Aakre, M.E., Fujitani, Y., Fujitani, S., Wright, AC.V.E., and Moses, H.L. 2006. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-signaling in cooperation with active Kras expression. Genes & Dev. 20(2006) 3147-3160.

    [68] Pasca di Magliano, M., Sekine, S., Ermilov, A., Ferris, J., Dlugosz, A.A., and Hebrok, M. 2006. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes & Dev. 20(2006) 3161-3173.

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