publication . Article . 2015

Multifaceted role of matrix metalloproteinases (MMPs)

Divya eSingh; Sanjeev Kumar Srivastava; Tapas K Chaudhuri; Ghanshyam eUpadhyay;
Open Access English
  • Published: 01 May 2015 Journal: Frontiers in Molecular Biosciences, volume 2 (issn: 2296-889X, eissn: 2296-889X, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved in the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in the brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood-brain barrier disruption, and modulation of α-synuclein pathology. High expression of MMPs is well documented in various neurological disorders including Parkinson's disease (PD), Alzheimer's disease (AD), Japanese encephalitis (JE), and Glaucoma. Although potentially critical, the role of MMPs in neuronal disorders is under-investiga...
Subjects
free text keywords: MMP2, Molecular Biosciences, glaucoma, Review, MMP9, neurodegenerative disorders, Japanese encephalitis, Biology (General), QH301-705.5
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publication . Article . 2015

Multifaceted role of matrix metalloproteinases (MMPs)

Divya eSingh; Sanjeev Kumar Srivastava; Tapas K Chaudhuri; Ghanshyam eUpadhyay;