Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required For Mitotic ATM Activation and the Spindle Checkpoint

Article, Other literature type English OPEN
Yang, Chunying; Tang, Xi; Guo, Xiaojing; Niikura, Yohei; Kitagawa, Katsumi; Cui, Kemi; Wong, Stephen T.C.; Fu, Li; Xu, Bo; (2011)
  • Publisher: Elsevier BV
  • Journal: Molecular Cell,volume 44,issue 4,pages597-608 (issn: 1097-2765)
  • Related identifiers: doi: 10.1016/j.molcel.2011.09.016, pmc: PMC3228519
  • Subject: Molecular Biology | Cell Biology | Article
    acm: GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
    mesheuropmc: enzymes and coenzymes (carbohydrates)

The ATM kinase plays a critical role in the maintenance of genetic stability. ATM is activated in response to DNA damage and is essential for cell cycle checkpoints. Here, we report that ATM is activated in mitosis in the absence of DNA damage. We demonstrate that mitot... View more
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