Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture

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Veistinen, Lotta; Takatalo, Maarit; Tanimoto, Yukiho; Kesper, Dörthe A.; Vortkamp, Andrea; Rice, David P. C.;
  • Publisher: Frontiers Research Foundation
  • Journal: Frontiers in Physiology,volume 3 (issn: 1664-042X, eissn: 1664-042X)
  • Related identifiers: pmc: PMC3342524, doi: 10.3389/fphys.2012.00121
  • Subject: craniosynostosis | suture | developmental biology | 313 Dentistry | Physiology | Original Research | bone | Gli3

Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder with polydactyly and syndactyly of the limbs and a broad spectrum of craniofacial abnormalities. Craniosynostosis of the metopic suture (interfrontal suture in mice) is an important but rare f... View more
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