Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms

Article English OPEN
Schouten, Philip C.; Grigoriadis, Anita; Kuilman, Thomas; Mirza, Hasan; Watkins, Johnathan A.; Cooke, Saskia A.; van Dyk, Ewald; Severson, Tesa M.; Rueda, Oscar M.; Hoogstraat, Marlous; Verhagen, Caroline V.M.; Natrajan, Rachael; Chin, Suet-Feung; Lips, Esther H.; Kruizinga, Janneke; Velds, Arno; Nieuwland, Marja; Kerkhoven, Ron M.; Krijgsman, Oscar; Vens, Conchita; Peeper, Daniel; Nederlof, Petra M.; Caldas, Carlos; Tutt, Andrew N.; Wessels, Lodewyk F.; Linn, Sabine C.;
  • Publisher: Molecular oncology
  • Journal: volume 9, issue 7, pages 1,274-86issn: 1574-7891, eissn: 1878-0261
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.17863/CAM.14417, doi: 10.1016/j.molonc.2015.03.002, pmc: PMC5528812
  • Subject: Breast Neoplasms | CHEMOTHERAPY | Research Support, Non-U.S. Gov't | HUMAN BREAST-TUMORS | CARCINOMAS | BRCA1 | SEGMENTATION | Randomized Controlled Trials as Topic | Gene Dosage | Female | Research Paper | PROMOTER HYPERMETHYLATION | Genes, BRCA1 | Datasets as Topic | GENES | Breast cancer | Research Papers | Classification | Copy number aberration profiles | COMPARATIVE GENOMIC HYBRIDIZATION | ARRAY-CGH | DNA Methylation | DEFICIENCY | Cohort Studies | CANCERS | Journal Article | Humans
    mesheuropmc: skin and connective tissue diseases

Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be 'BRCA1-like' or 'non-BRCA1-like', which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mu... View more
Share - Bookmark