Effects of EpCAM overexpression on human breast cancer cell lines

Article English OPEN
Gostner, Johanna M; Fong, Dominic; Wrulich, Oliver A; Lehne, Florian; Zitt, Marion; Hermann, Martin; Krobitsch, Sylvia; Martowicz, Agnieszka; Gastl, Guenther; Spizzo, Gilbert;

<p>Abstract</p> <p>Background</p> <p>Recently, EpCAM has attracted major interest as a target for antibody- and vaccine-based cancer immunotherapies. In breast cancer, the EpCAM antigen is overexpressed in 30-40% of all cases and this increased expression correlates wit... View more
  • References (46)
    46 references, page 1 of 5

    1. Tandon AK, Clark GM, Chamness GC, McGuire WL: Association of the 323/ A3 surface glycoprotein with tumor characteristics and behavior in human breast cancer. Cancer Res 1990, 50:3317-3321.

    2. Gastl G, Spizzo G, Obrist P, Dunser M, Mikuz G: Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 2000, 356:1981-1982.

    3. Spizzo G, Went P, Dirnhofer S, Obrist P, Simon R, Spichtin H, Maurer R, Metzger U, Von Castelberg B, Bart R, et al: High Ep-CAM Expression is Associated with Poor Prognosis in Node-positive Breast Cancer. Breast Cancer Res Treat 2004, 86:207-213.

    4. Schmidt M, Hasenclever D, Schaeffer M, Boehm D, Cotarelo C, Steiner E, Lebrecht A, Siggelkow W, Weikel W, Schiffer-Petry I, et al: Prognostic effect of epithelial cell adhesion molecule overexpression in untreated nodenegative breast cancer. Clin Cancer Res 2008, 14:5849-5855.

    5. Spizzo G, Obrist P, Ensinger C, Theurl I, Dunser M, Ramoni A, Gunsilius E, Eibl G, Mikuz G, Gastl G: Prognostic significance of Ep-CAM AND Her-2/ neu overexpression in invasive breast cancer. Int J Cancer 2002, 98:883-888.

    6. Schmidt M, Scheulen ME, Dittrich C, Obrist P, Marschner N, Dirix L, Schmidt M, Ruttinger D, Schuler M, Reinhardt C, et al: An open-label, randomized phase II study of adecatumumab, a fully human antiEpCAM antibody, as monotherapy in patients with metastatic breast cancer. Ann Oncol 2009.

    7. Shen J, Zhu Z: Catumaxomab, a rat/murine hybrid trifunctional bispecific monoclonal antibody for the treatment of cancer. Curr Opin Mol Ther 2008, 10:273-284.

    8. Balzar M, Prins FA, Bakker HA, Fleuren GJ, Warnaar SO, Litvinov SV: The structural analysis of adhesions mediated by Ep-CAM. Exp Cell Res 1999, 246:108-121.

    9. Litvinov SV, Balzar M, Winter MJ, Bakker HA, Briaire-de Bruijn IH, Prins F, Fleuren GJ, Warnaar SO: Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J Cell Biol 1997, 139:1337-1348.

    10. Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O: The carcinomaassociated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 2004, 23:5748-5758.

  • Related Organizations (3)
  • Metrics
Share - Bookmark