publication . Article . 2012

画像化法:89Zr-トランスフェリン画像化法を用いた、MYC活性状態の注釈付け

Samuel L. Rice; John Wongvipat; Charles L. Sawyers; Michael J. Evans; Jason P. Holland; Jason S. Lewis;
Open Access English
  • Published: 23 Sep 2012 Journal: Nature medicine, volume 18, issue 10, pages 1,586-1,591 (issn: 1078-8956, eissn: 1546-170X, Copyright policy)
Abstract
A non-invasive technology that quantitatively measures the activity of oncogenic signaling pathways could broadly impact cancer diagnosis and treatment using targeted therapies. Here we describe the development of 89Zr-desferrioxamine transferrin (89Zr-Tf), a novel positron emission tomography (PET) radiotracer that binds the transferrin receptor 1 (TFRC, CD71) with high avidity. 89Zr-Tf produces high contrast PET images that quantitatively reflect treatment-induced changes in MYC-regulated TFRC expression in a MYC oncogene-driven prostate cancer xenograft model. Moreover, 89Zr-Tf imaging can detect the in situ development of prostate cancer in a transgenic MYC ...
Subjects
free text keywords: Article, Zirconium-89, transferrin, TFRC, CD71, inflammation, prostate cancer, MYC, positron-emission tomography, PET/CT, oncogene, General Biochemistry, Genetics and Molecular Biology, General Medicine
Funded by
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Molecular Imaging: Training for Oncology
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R25CA096945-01
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| ANIMAL NMR AND RADIONUCLIDE IMAGING
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R24CA083084-04S1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| RATIONAL DESIGN OF PROSTATE-SPECIFIC MEMBRANE ANTIGEN DNA VACCINES
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P50CA092629-10
  • Funding stream: NATIONAL CANCER INSTITUTE
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