Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations

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Hu, Y; Tanaka, T; Zhu, J; Guan, W; Wu, JHY; Psaty, BM; McKnight, B; King, IB; Sun, Q; Richard, M; Manichaikul, A; Frazier-Wood, AC; Kabagambe, EK; Hopkins, PN; Ordovas, JM; Ferrucci, L; Bandinelli, S; Arnett, DK; Chen, YI; Liang, S; Siscovick, DS; Tsai, MY; Rich, SS; Fornage, M; Hu, FB; Rimm, EB; Jensen, MK; Lemaitre, RN; Mozaffarian, D; Steffen, LM; ... view all 33 authors
(2017)
  • Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
  • Journal: volume 58,issue 5issn: 0022-2275, eissn: 1539-7262
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1194/jlr.P071860
  • Subject: C-REACTIVE PROTEIN | fatty acid/metabolism | ADIPOSE-TISSUE | OLDER CHINESE | MONOUNSATURATED FATTY-ACIDS | METABOLIC SYNDROME | PALMITOLEIC ACID | genetics | NOVO LIPOGENESIS PATHWAY | fatty acid/desaturases | fatty acid/biosynthesis | CORONARY-HEART-DISEASE | RISK | GENOME-WIDE ASSOCIATION | monounsaturated fatty acid

MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D, and metabolic synd... View more
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