SH2 domains: modulators of nonreceptor tyrosine kinase activity

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Filippakopoulos, Panagis; Müller, Susanne; Knapp, Stefan;
  • Publisher: Elsevier Science
  • Journal: Current Opinion in Structural Biology,volume 19,issue 6,pages643-649 (issn: 0959-440X, eissn: 1879-033X)
  • Related identifiers: doi: 10.1016/, pmc: PMC2791838
  • Subject: Molecular Biology | Structural Biology | Article
    mesheuropmc: animal structures

The Src homology 2 (SH2) domain is a sequence-specific phosphotyrosine-binding module present in many signaling molecules. In cytoplasmic tyrosine kinases, the SH2 domain is located N-terminally to the catalytic kinase domain (SH1) where it mediates cellular localizatio... View more
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