SH2 domains: modulators of nonreceptor tyrosine kinase activity
Filippakopoulos, Panagis; Müller, Susanne; Knapp, Stefan;
- Publisher: Elsevier Science
- Journal: Current Opinion in Structural Biology,volume 19,issue 6,pages643-649 (issn: 0959-440X, eissn: 1879-033X)
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Related identifiers: , - Subject: Molecular Biology | Structural Biology | Articlemesheuropmc: animal structures
The Src homology 2 (SH2) domain is a sequence-specific phosphotyrosine-binding module present in many signaling molecules. In cytoplasmic tyrosine kinases, the SH2 domain is located N-terminally to the catalytic kinase domain (SH1) where it mediates cellular localizatio... View more
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UNIVERSITY OF OXFORD 90%University of Oxford ( University of Oxford ) United KingdomWebsite url: http://www.ox.ac.uk/90%University Of Oxford 90% - Metrics
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