SH2 domains: modulators of nonreceptor tyrosine kinase activity

Article English OPEN
Filippakopoulos, Panagis; Müller, Susanne; Knapp, Stefan;
(2009)

The Src homology 2 (SH2) domain is a sequence-specific phosphotyrosine-binding module present in many signaling molecules. In cytoplasmic tyrosine kinases, the SH2 domain is located N-terminally to the catalytic kinase domain (SH1) where it mediates cellular localizatio... View more
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