Ontogeny of Human IgE-expressing B Cells and Plasma Cells

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Ramadani, Faruk; Bowen, Holly; Upton, Nadine; Hobson, Philip S; Chan, Yih-Chih; Chen, Jiun-Bo; Chang, Tse Wen; McDonnell, James M; Sutton, Brian J; Fear, David Jonathan; Gould, Hannah J;
  • Publisher: John Wiley and Sons Inc.
  • Journal: volume 72,issue 1,pages66-76issn: 0105-4538, eissn: 1398-9995
  • Related identifiers: doi: 10.1111/all.12911, pmc: PMC5107308
  • Subject: Experimental Allergy and Immunology | Original Article | germinal centre | ORIGINAL ARTICLES | IgE class switching | allergy | human B cells | plasma cell

<p>BACKGROUND: IgE-expressing (IgE<sup>+</sup>) plasma cells (PCs) provide a continuous source of allergen specific IgE that is central to allergic responses. The extreme sparsity of IgE<sup>+</sup> cells in vivo has confined their study almost entirely to mouse models.... View more
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