Ontogeny of human IgE‐expressing B cells and plasma cells

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Ramadani, F. ; Bowen, H. ; Upton, N. ; Hobson, P. S. ; Chan, Y.‐C. ; Chen, J.‐B. ; Chang, T. W. ; McDonnell, J. M. ; Sutton, B. J. ; Fear, D. J. ; Gould, H. J. (2016)
  • Publisher: John Wiley and Sons Inc.
  • Journal: Allergy, volume 72, issue 1, pages 66-76 (issn: 0105-4538, eissn: 1398-9995)
  • Related identifiers: doi: 10.1111/all.12911, pmc: PMC5107308
  • Subject: Experimental Allergy and Immunology | Original Article | germinal centre | ORIGINAL ARTICLES | IgE class switching | allergy | human B cells | plasma cell

<p>BACKGROUND: IgE-expressing (IgE<sup>+</sup>) plasma cells (PCs) provide a continuous source of allergen specific IgE that is central to allergic responses. The extreme sparsity of IgE<sup>+</sup> cells in vivo has confined their study almost entirely to mouse models.... View more
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