Short-and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue

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Gathercole, LL; Morgan, SA; Bujalska, IJ; Stewart, PM; Tomlinson, JW;
(2011)

Background: Endogenous or exogenous glucocorticoid (GC) excess (Cushing's syndrome) is characterized by increased adiposity and insulin resistance. Although GCs cause global insulin resistance in vivo, we have previously shown that GCs are able to augment insulin action... View more
  • References (21)
    21 references, page 1 of 3

    Van Staa, TP, Leufkens, HG, Abenhaim, L, Begaud, B, Zhang, B, Cooper, C. Use of oral corticosteroids in the United Kingdom. QJM. 2000; 93/2: 105-111

    Larsson, H, Ahren, B. Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. J Clin Endocrinol Metab. 1996; 81/12: 4428-4432

    Gathercole, LL, Bujalska, IJ, Stewart, PM, Tomlinson, JW. Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue. J Clin Endocrinol Metab. 2007; 92/11: 4332-4339

    Tomlinson, JJ, Boudreau, A, Wu, D, Abdou, SH, Carrigan, A, Gagnon, A. Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors. Mol Endocrinol. 2010; 24/1: 104-113

    Saad, MJ, Folli, F, Kahn, JA, Kahn, CR. Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest. 1993; 92/4: 2065-2072

    Nosadini, R, Del, PS, Tiengo, A, Valerio, A, Muggeo, M, Opocher, G. Insulin resistance in Cushing's syndrome. J Clin Endocrinol Metab. 1983; 57/3: 529-536

    Rui, L, Aguirre, V, Kim, JK, Shulman, GI, Lee, A, Corbould, A. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest. 2001; 107/2: 181-189

    Bujalska, IJ, Gathercole, LL, Tomlinson, JW, Darimont, C, Ermolieff, J, Fanjul, AN. A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. J Endocrinol. 2008; 197/2: 297-307

    Hauner, H, Schmid, P, Pfeiffer, EF. Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells. J Clin Endocrinol Metab. 1987; 64/4: 832-835

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