Fifteen new risk loci for coronary artery disease highlight arterial wall-specific mechanisms

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Howson, Joanna M.M. ; Zhao, Wei ; Barnes, Daniel R. ; Ho, Weang-Kee ; Young, Robin ; Paul, Dirk S. ; Waite, Lindsay L. ; Freitag, Daniel F. ; Fauman, Eric B. ; Salfati, Elias L. ; Sun, Benjamin B. ; Eicher, John D. ; Johnson, Andrew D. ; Sheu, Wayne H.H. ; Nielsen, Sune F. ; Lin, Wei-Yu ; Surendran, Praveen ; Malarstig, Anders ; Wilk, Jemma B. ; Tybjærg-Hansen, Anne ; Rasmussen, Katrine L. ; Kamstrup, Pia R. ; Deloukas, Panos ; Erdmann, Jeanette ; Kathiresan, Sekar ; Samani, Nilesh J. ; Schunkert, Heribert ; Watkins, Hugh ; Do, Ron ; Rader, Daniel J. ... view all 72 authors (2017)

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An ef... View more