Opioid Mechanism Involvement in the Synergism Produced by the Combination of Diclofenac and Caffeine in the Formalin Model

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Flores-Ramos, José María ; Díaz-Reval, M. Irene (2013)
  • Publisher: Hindawi Publishing Corporation
  • Journal: ISRN Pain, volume 2,013 (eissn: 2314-4718)
  • Related identifiers: pmc: PMC4893401, doi: 10.1155/2013/196429
  • Subject: Research Article | Article Subject
    mesheuropmc: stomatognathic diseases

Analgesics can be administered in combination with caffeine for improved analgesic effectiveness in a process known as synergism. The mechanisms by which these combinations produce synergism are not yet fully understood. The aim of this study was to analyze whether the ... View more
  • References (32)
    32 references, page 1 of 4

    Burke, A., Smyth, E., FitzGerald, G. A., Brunton, L. L., Lazo, J. S., Parker, K. L.. Analgesic-antypiretic agents; pharmacotherapy of gout. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 2006: 697-698

    Ku, E. C., Lee, W., Kothari, H. V., Scholer, D. W.. Effect of diclofenac sodium on the arachidonic acid cascade. American Journal of Medicine. 1986; 80 (4): 18-23

    Sacerdote, P., Monza, G., Mantegazza, P., Paneri, A. E.. Diclofenac and pirprofen modify pituitary and hypothalamic beta-endorphin concentrations. Pharmacological Research Communications. 1985; 17 (8): 679-684

    Bjorkman, R., Hedner, J., Hedner, T., Henning, M.. Central, naloxone-reversible antinociception by diclofenac in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology. 1990; 342 (2): 171-176

    Bjorkman, R. L., Hedner, T., Hallman, K. M., Henning, M., Hedner, J.. Localization of the central antinociceptive effects of diclofenac in the rat. Brain Research. 1992; 590 (1-2): 66-73

    Miranda, H. F., Sierralta, F., Pinardi, G.. An isobolographic analysis of the adrenergic modulation of diclofenac antinociception. Anesthesia and Analgesia. 2001; 93 (2): 430-435

    Pinardi, G., Sierralta, F., Miranda, H. F.. Adrenergic mechanisms in antinociceptive effects of non steroidal anti-inflammatory drugs in acute thermal nociception in mice. Inflammation Research. 2002; 51 (5): 219-222

    Tonussi, C. R., Ferreira, S. H.. Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. European Journal of Pharmacology. 1994; 251 (2-3): 173-179

    Ortiz, M., Granados-Soto, V., Castañeda-Hernández, G.. The NO-cGMP-K+ channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin. Pharmacology Biochemistry and Behavior. 2003; 76: 187-195

    Alves, D. P., Tatsuo, M. A. F., Leite, R., Duarte, I. D. G.. Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation. Life Sciences. 2004; 74 (20): 2577-2591

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