Dental developmental abnormalities in a patient with subtelomeric 7q36 deletion syndrome may confirm a novel role for the SHH gene☆
Linhares, Natália D.
Salgado, Mauro Ivan
Rodrigues, Tatiane C.
da Costa, Silvia S.
Valadares, Eugênia R.
- Publisher: Elsevier
(issn: 2214-5400, eissn: 2214-5400)
7q deletion | Human HTR5A protein | OFC, occipitofrontal circumference | Short Communication | Human MNX1 protein | Comparative genomic hybridization | ASD, autism spectrum disorder | BERA, brainstem evoked response audiometry | CNV, copy number variation | Human EN2 protein | Human SHH protein | aCGH, array comparative genomic hybridization | FISH, fluorescence in situ hybridization
mesheuropmc: stomatognathic diseases | stomatognathic system
Studies in mice demonstrated that the Shh gene is crucial for normal development of both incisors and molars, causing a severe retardation in tooth growth, which leads to abnormal placement of the tooth in the jaw and disrupted tooth morphogenesis. In humans the SHH gen...