C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.

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Zheng, Yanqiu; Brady, Owen A.; Meng, Peter S.; Mao, Yuxin; Hu, Fenghua;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 6,issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3115958, doi: 10.1371/journal.pone.0021023
  • Subject: Neurobiology of Disease and Regeneration | Research Article | Biology | Molecular Cell Biology | Neuroscience | Molecular Neuroscience | Medicine | Neurodegenerative Diseases | Q | R | Science | Dementia | Neurology
    mesheuropmc: mental disorders | nervous system diseases

Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is a main determinant of progranulin level in the brain. In this study, we... View more
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