Mechanisms of aneuploidy and its suppression by tumour suppressor proteins

Article, Review English OPEN
Thoma, Claudio R.; Toso, Alberto; Meraldi, Patrick; Krek, Wilhelm;
  • Publisher: EMH, Schweizerischer Ärzte-Verlag AG
  • Journal: issn: 1424-7860
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.3929/ethz-b-000035814, doi: 10.4414/smw.2011.13170
  • Subject: Adenomatous Polyposis Coli Protein/genetics/metabolism | Chromosomal Instability/genetics | Genes, cdc | Neoplasms/genetics/metabolism | Aneuploidy; Whole chromosomal instability; Tumour suppressor proteins | Tumor Suppressor Proteins/genetics/metabolism | Von Hippel-Lindau Tumor Suppressor Protein/genetics/metabolism | Aneuploidy | Retinoblastoma Protein/genetics/metabolism | Humans | Repressor Proteins/genetics/metabolism | Tumor Suppressor Protein p53/genetics/metabolism
    • ddc: ddc:612

Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provi... View more
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