Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits

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Nishimichi, Norihisa ; Kawashima, Nagako ; Yokosaki, Yasuyuki (2015)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 5 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: pmc: PMC4563375, doi: 10.1038/srep13756
  • Subject: Article

Identification of epitopes for integrin-blocking monoclonal antibodies (mAbs) has aided our understanding of structure-function relationship of integrins. We mapped epitopes of chicken anti-integrin-α8-subunit-blocking mAbs by mutational analyses, examining regions that... View more
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