Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

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Allaman, I.; Gavillet, M.; Bélanger, M.; Laroche, T.; Viertl, D.; Lashuel, H.A.; Magistretti, P.J.;
  • Journal: eissn: 1529-2401
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1523/JNEUROSCI.5098-09.2010
  • Subject: Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Alzheimer Disease/physiopathology; Amyloid beta-Peptides/metabolism; Amyloid beta-Peptides/toxicity; Animals; Animals, Newborn; Astrocytes/drug effects; Astrocytes/metabolism; Brain/metabolism; Brain/pathology; Brain/physiopathology; Cell Communication/drug effects; Cell Communication/physiology; Cell Survival/drug effects; Cell Survival/physiology; Cells, Cultured; Energy Metabolism/drug effects; Energy Metabolism/physiology; Free Radicals/metabolism; Glucose/metabolism; Glutathione/metabolism; Hydrogen Peroxide/metabolism; Mice; Nerve Degeneration/metabolism; Nerve Degeneration/pathology; Nerve Degeneration/physiopathology; Neurons/metabolism; Oxidative Stress/drug effects; Oxidative Stress/physiology; Peptide Fragments/toxicity; Phenotype; Phosphatidylinositol 3-Kinases/antagonists & inhibitors; Phosphatidylinositol 3-Kinases/metabolism
    mesheuropmc: mental disorders

Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostasis, contributi... View more
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