IL-13 is a central mediator of chemical-induced airway hyperreactivity in mice
Devos, Fien C.
Hoet, Peter H. M.
Vanoirbeek, Jeroen A. J.
- Publisher: Public Library of Science
(issn: 1932-6203, eissn: 1932-6203)
Mouse Models | Animal Models | Research Article | Diagnostic Medicine | Anatomy | Signs and Symptoms | Pathology and Laboratory Medicine | Lymphatic System | Molecular Development | White Blood Cells | Immune Response | Inflammation | Immune System | Cytokines | Experimental Organism Systems | Immunology | Cellular Types | Biology and Life Sciences | Lymphocytes | Immune Physiology | Developmental Biology | Research and Analysis Methods | Blood Cells | Physiology | Immune Cells | Medicine | Pulmonology | Asthma | Animal Cells | Innate Immune System | Q | R | Cell Biology | Model Organisms | Lymph Nodes | T Cells | Science | Medicine and Health Sciences
Background: While the importance of the Th2 cytokine IL-13 as a central mediator of airway hyperreactivity (AHR) has been described in allergic protein-induced asthma, this has never been investigated in chemical-induced asthma.
Objective: We examined the importance...