IL-13 is a central mediator of chemical-induced airway hyperreactivity in mice

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Devos, Fien C. ; Pollaris, Lore ; Cremer, Jonathan ; Seys, Sven ; Hoshino, Tomoaki ; Ceuppens, Jan ; Talavera, Karel ; Nemery, Benoit ; Hoet, Peter H. M. ; Vanoirbeek, Jeroen A. J. (2017)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 12, issue 7 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC5509233, doi: 10.1371/journal.pone.0180690
  • Subject: Mouse Models | Animal Models | Research Article | Diagnostic Medicine | Anatomy | Signs and Symptoms | Pathology and Laboratory Medicine | Lymphatic System | Molecular Development | White Blood Cells | Immune Response | Inflammation | Immune System | Cytokines | Experimental Organism Systems | Immunology | Cellular Types | Biology and Life Sciences | Lymphocytes | Immune Physiology | Developmental Biology | Research and Analysis Methods | Blood Cells | Physiology | Immune Cells | Medicine | Pulmonology | Asthma | Animal Cells | Innate Immune System | Q | R | Cell Biology | Model Organisms | Lymph Nodes | T Cells | Science | Medicine and Health Sciences

Background: While the importance of the Th2 cytokine IL-13 as a central mediator of airway hyperreactivity (AHR) has been described in allergic protein-induced asthma, this has never been investigated in chemical-induced asthma. Objective: We examined the importance... View more
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