publication . Article . 2016

Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse.

Yeo, S.‐H.; Kyle, V.; Morris, P. G.; Jackman, S.; Sinnett‐Smith, L. C.; Schacker, M.; Chen, C.; Colledge, W. H.;
Open Access
  • Published: 28 Oct 2016 Journal: Journal of Neuroendocrinology, volume 28 (issn: 0953-8194, Copyright policy)
  • Publisher: Wiley
Abstract
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurones are found in two locations in the rodent hypothalamus: one in the arcuate nucleus (ARC) and another in the RP3V region, which includes the anteroventral periventricular nucleus (AVPV). Detailed mapping of the fibre distribution of Kiss1 neurones will help with our understanding of the action of these neurones in other regions of the brain. We have generated a transgenic mouse in which the Kiss1 coding region is disrupted by a CRE‐GFP transgene so that expression of the CRE recombinase protein is driven from the Kiss...
Subjects
Medical Subject Headings: nervous system
free text keywords: Anteroventral periventricular nucleus, Hypothalamus, Kisspeptin, Nucleus, medicine.anatomical_structure, medicine, Amygdala, Lateral hypothalamus, Neuropeptide, Internal medicine, medicine.medical_specialty, Biology, Transgene, Endocrinology, Original Article, Original Articles, Kiss‐CRE, transgenic, mouse, tdTomato, CLARITY, neuronal distribution
Related Organizations
30 references, page 1 of 2

1 Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. Endocr Rev 2009; 30: 713–743.19770291 [OpenAIRE] [PubMed]

2 Colledge WH, Doran J, Mei H. Model systems for studying kisspeptin signalling: mice and cells. Adv Exp Med Biol 2013; 784: 481–503.23550020 [PubMed]

3 Kinoshita M, Tsukamura H, Adachi S, Matsui H, Uenoyama Y, Iwata K, Yamada S, Inoue K, Ohtaki T, Matsumoto H, Maeda K. Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Endocrinology 2005; 146: 4431–4436.15976058 [PubMed]

4 Clarkson J, d'Anglemont de Tassigny X, Moreno AS, Colledge WH, Herbison AE. Kisspeptin‐GPR54 signaling is essential for preovulatory gonadotropin‐releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci 2008; 28: 8691–8697.18753370 [OpenAIRE] [PubMed]

5 Smith JT, Li Q, Yap KS, Shahab M, Roseweir AK, Millar RP, Clarke IJ. Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence. Endocrinology 2011; 152: 1001–1012.21239443 [PubMed]

6 Clarke IJ, Smith JT, Caraty A, Goodman RL, Lehman MN. Kisspeptin and seasonality in sheep. Peptides 2009; 30: 154–163.18838092 [OpenAIRE] [PubMed]

7 Castellano JM, Bentsen AH, Mikkelsen JD, Tena‐Sempere M. Kisspeptins: bridging energy homeostasis and reproduction. Brain Res 2010; 1364: 129–138.20800054 [OpenAIRE] [PubMed]

8 Yeo SH, Herbison AE. Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain. Endocrinology 2011; 152: 2387–2399.21486932 [PubMed]

9 Hoong YS, Boehm U, Herbison AE, Campbell RE. Conditional viral tract‐tracing delineates the projections of the distinct kisspeptin neuron populations to gonadotropin‐releasing hormone (GnRH) neurons in the mouse. Endocrinology 2015; 156: 2582–2594.25856430 [PubMed]

10 d'Anglemont dTX, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, Aparicio SA, Colledge WH. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA 2007; 104: 10714–10719.17563351 [OpenAIRE] [PubMed]

11 Matsuda T, Cepko CL. Controlled expression of transgenes introduced by in vivo electroporation. Proc Natl Acad Sci USA 2007; 104: 1027–1032.17209010 [OpenAIRE] [PubMed]

12 Steyn FJ, Wan Y, Clarkson J, Veldhuis JD, Herbison AE, Chen C. Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice. Endocrinology 2013; 154: 4939–4945.24092638 [OpenAIRE] [PubMed]

13 Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, Eacker SM, Clifton DK, Steiner RA. Differential regulation of KiSS‐1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 2005; 146: 2976–2984.15831567 [PubMed]

14 Chung K, Deisseroth K. CLARITY for mapping the nervous system. Nat Methods 2013; 10: 508–513.23722210 [PubMed]

15 Gonzalez‐Bellido PT, Wardill TJ. Labeling and confocal imaging of neurons in thick invertebrate tissue samples. Cold Spring Harb Protoc 2012; 2012: 969–983.22949711 [PubMed]

30 references, page 1 of 2
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2016

Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse.

Yeo, S.‐H.; Kyle, V.; Morris, P. G.; Jackman, S.; Sinnett‐Smith, L. C.; Schacker, M.; Chen, C.; Colledge, W. H.;