Progranulin, a Glycoprotein Deficient in Frontotemporal Dementia, Is a Novel Substrate of Several Protein Disulfide Isomerase Family Proteins

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Almeida, Sandra ; Zhou, Lijuan ; Gao, Fen-Biao (2011)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 6, issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3196579, doi: 10.1371/journal.pone.0026454
  • Subject: Neurobiology of Disease and Regeneration | Animal Models | Research Article | Biology | Molecular Cell Biology | Neuroscience | Mental Health | Chaperone Proteins | Molecular Neuroscience | Medicine | Psychiatry | Protein Interactions | Membranes and Sorting | Q | Mouse | R | Signaling Pathways | Model Organisms | Proteins | Science | Biochemistry | Dementia | Neurology
    mesheuropmc: mental disorders

The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for about 20% of cases of familial frontotemporal dementia. However, little is known about the molecular mechanisms that govern the level and secretion of progranulin. Here w... View more
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