Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins.

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Sandra Almeida; Lijuan Zhou; Fen-Biao Gao;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 6,issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3196579, doi: 10.1371/journal.pone.0026454
  • Subject: Neurobiology of Disease and Regeneration | Animal Models | Research Article | Biology | Molecular Cell Biology | Neuroscience | Mental Health | Chaperone Proteins | Molecular Neuroscience | Medicine | Psychiatry | Protein Interactions | Membranes and Sorting | Mouse | Q | R | Signaling Pathways | Model Organisms | Proteins | Biochemistry | Science | Dementia | Neurology
    mesheuropmc: mental disorders

The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for about 20% of cases of familial frontotemporal dementia. However, little is known about the molecular mechanisms that govern the level and secretion of progranulin. Here w... View more
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