Progranulin, a Glycoprotein Deficient in Frontotemporal Dementia, Is a Novel Substrate of Several Protein Disulfide Isomerase Family Proteins
- Publisher: Public Library of Science
(issn: 1932-6203, eissn: 1932-6203)
Neurobiology of Disease and Regeneration | Animal Models | Research Article | Biology | Molecular Cell Biology | Neuroscience | Mental Health | Chaperone Proteins | Molecular Neuroscience | Medicine | Psychiatry | Protein Interactions | Membranes and Sorting | Q | Mouse | R | Signaling Pathways | Model Organisms | Proteins | Science | Biochemistry | Dementia | Neurology
mesheuropmc: mental disorders
The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for about 20% of cases of familial frontotemporal dementia. However, little is known about the molecular mechanisms that govern the level and secretion of progranulin. Here w...