Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors

Article, Other literature type English OPEN
Huisman, Christian; Wisman, G. Bea A.; Kazemier, Hinke G.; van Vugt, Marcel A. T. M.; van der Zee, Ate G. J.; Schuuring, Ed; Rots, Marianne G.;
  • Publisher: John Wiley and Sons Inc.
  • Related identifiers: pmc: PMC5528488, doi: 10.1016/j.molonc.2013.02.017
  • Subject: FINGER | GROWTH-FACTOR-A | EXPRESSION | DRUGS | THERAPY | CELL-CYCLE | REACTIVATION | Novel antitumor agents | Papers | DNA METHYLATION | ACETYLATION | Tumor suppressor genes | Methylation biomarkers | Artificial Transcription Factors | Cellular responses to anticancer drugs | PROMOTER | DNA methylation/epigenetics

C13ORF18 is frequently hypermethylated in cervical cancer but not in normal cervix and might serve as a biomarker for the early detection of cervical cancer in scrapings. As hypermethylation is often observed for silenced tumor suppressor genes (TSGs), hypermethylated b... View more
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