SPARC promotes cell invasion in vivo by decreasing type IV collagen levels in the basement membrane

Article, Preprint English OPEN
Jayadev, Ranjay; Ihara, Shinji; Sherwood, David; Miley, Ginger; Chi, Qiuyi; Blebea, Catherine; Morrissey, Meghan;
(2016)
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 12,issue 2 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: doi: 10.1371/journal.pgen.1005905, doi: 10.1101/037218, pmc: PMC4771172
  • Subject: Molecular Biology | Caenorhabditis | Animal Models | Research Article | Molecular Biology Assays and Analysis Techniques | Gene Expression and Vector Techniques | Basement Membrane | Epigenetics | Oncology | QH426-470 | Genetics | Physical Sciences | Collagens | Metastasis | Fluorescence | Proteins | Molecular Biology Techniques | Physics | Animals | Biology and Life Sciences | RNA | Research and Analysis Methods | Nematoda | bepress|Life Sciences|Cell and Developmental Biology|Cell Biology | Genetic interference | Caenorhabditis Elegans | Nucleic acids | Basic Cancer Research | bepress|Life Sciences|Biology | Cell Biology | Electromagnetic Radiation | Luminescence | Model Organisms | Cellular Structures and Organelles | Biochemistry | Organisms | Hyperexpression Techniques | Medicine and Health Sciences | Invertebrates | RNA interference | Extracellular Matrix | Gene expression

Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular processes including integrin-mediated cell adhesion, cell signaling pathways, ... View more
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