SPARC promotes cell invasion in vivo by decreasing type IV collagen levels in the basement membrane

Article, Preprint English OPEN
Jayadev, Ranjay; Ihara, Shinji; Sherwood, David; Miley, Ginger; Chi, Qiuyi; Blebea, Catherine; Morrissey, Meghan;
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 12,issue 2 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: doi: 10.1371/journal.pgen.1005905, doi: 10.1101/037218, pmc: PMC4771172
  • Subject: Molecular Biology | Caenorhabditis | Animal Models | Research Article | Molecular Biology Assays and Analysis Techniques | Gene Expression and Vector Techniques | Basement Membrane | Epigenetics | Oncology | QH426-470 | Genetics | Physical Sciences | Collagens | Metastasis | Fluorescence | Proteins | Molecular Biology Techniques | Physics | Animals | Biology and Life Sciences | RNA | Research and Analysis Methods | Nematoda | bepress|Life Sciences|Cell and Developmental Biology|Cell Biology | Genetic interference | Caenorhabditis Elegans | Nucleic acids | Basic Cancer Research | bepress|Life Sciences|Biology | Cell Biology | Electromagnetic Radiation | Luminescence | Model Organisms | Cellular Structures and Organelles | Biochemistry | Organisms | Hyperexpression Techniques | Medicine and Health Sciences | Invertebrates | RNA interference | Extracellular Matrix | Gene expression

Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular processes including integrin-mediated cell adhesion, cell signaling pathways, ... View more
  • References (104)
    104 references, page 1 of 11

    1. Rowe RG, Weiss SJ. Breaching the basement membrane: who, when and how? Trends Cell Biol. 2008;18(11):560-74.

    2. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.

    3. Kelley LC, Lohmer LL, Hagedorn EJ, Sherwood DR. Traversing the basement membrane in vivo: A diversity of strategies. J Cell Biol. 2014;204(3):291-302.

    4. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009;139(5):891-906.

    5. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012;196(4):395-406.

    6. Yurchenco PD. Basement membranes: cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol. 2011;3(2).

    7. Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, et al. A sulfilimine bond identified in collagen IV. Science. 2009;325(5945):1230-4.

    8. Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, et al. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(1):331-6.

    9. Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development. 2004;131(7):1619-28.

    10. Kubota Y, Nagata K, Sugimoto A, Nishiwaki K. Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease. Genetics. 2012;190(4):1379-88.

  • Related Research Results (2)
  • Metrics
    No metrics available
Share - Bookmark