The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis

Article, Other literature type English OPEN
Eliana M Lacerda ; Erinna W Bowman ; Jacqueline M Cliff ; Caroline C Kingdon ; Elizabeth C King ; Ji-Sook Lee ; Taane G Clark ; Hazel M Dockrell ; Eleanor M Riley ; Hayley Curran ; Luis Nacul (2017)
  • Publisher: Ubiquity Press
  • Journal: Open Journal of Bioresources (issn: 2056-5542, eissn: 2056-5542)
  • Related identifiers: doi: 10.5334/ojb.28
  • Subject: R858-859.7 | database | R | Computer applications to medicine. Medical informatics | medicine, pathology, immunology, genetics, epidemiology | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; multiple sclerosis; biobank; biospecimen; database | multiple sclerosis | biospecimen | Medicine | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | biobank | Article

<p class="p1">The UK ME/CFS Biobank was launched in August 2011 following extensive consultation with professionals and patient representatives. The bioresource aims to enhance research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), related to pathophysiology, biomarkers and therapeutic approaches. The cohort includes 18–60 year olds, encompassing 284 clinically-confirmed ME/CFS cases, 60 neurologist-diagnosed multiple sclerosis (MS) cases, and 135 healthy individuals. The Biobank contains blood samples, aliquoted into serum, plasma, peripheral blood mononuclear cells (PBMC), red blood cells/granulocyte pellet, whole blood, and RNA (totalling 29,863 aliquots). Extensive dataset (700 clinical and socio-demographic variables/participant) enables comprehensive phenotyping. Potential reuse is conditional to ethical approval.</p>
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