Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice

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Alkan, Manal; Machavoine, François; Rignault, Rachel; Dam, Julie; Dy, Michel; Thieblemont, Nathalie;
  • Publisher: Hindawi Publishing Corporation
  • Journal: Journal of Diabetes Research, volume 2,015 (issn: 2314-6745, eissn: 2314-6753)
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  • Identifiers: pmc: PMC4452174, doi: 10.1155/2015/965056
  • Subject: Research Article | RC648-665 | [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology | [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology | Diseases of the endocrine glands. Clinical endocrinology | Article Subject

International audience; Recent evidence has highlighted the role of histamine in inflammation. Since this monoamine has also been strongly implicated in the pathogenesis of type-1 diabetes, we assessed its effect in the nonobese diabetic (NOD) mouse model. To this end, ... View more
  • References (49)
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