Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

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Liang, Jingjing; Le, Thu H.; Edwards, Digna R. Velez; Tayo, Bamidele O.; Gaulton, Kyle J.; Smith, Jennifer A.; Lu, Yingchang; Jensen, Richard A.; Chen, Guanjie; Yanek, Lisa R.; Schwander, Karen; Tajuddin, Salman M.; Sofer, Tamar; Kim, Wonji; Kayima, James; McKenzie, Colin A.; Fox, Ervin; Nalls, Michael A.; Young, J. Hunter; Sun, Yan V.; Lane, Jacqueline M.; Cechova, Sylvia; Zhou, Jie; Tang, Hua; Fornage, Myriam; Musani, Solomon K.; Wang, Heming; Lee, Juyoung; Adeyemo, Adebowale; Dreisbach, Albert W.; ... view all 79 authors
(2017)
  • Publisher: Public Library of Science
  • Journal: volume 13,issue 5issn: 1553-7390, eissn: 1553-7404
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pgen.1006728., doi: 10.1371/journal.pgen.1006728, pmc: PMC5446189
  • Subject: Computational Biology | Human Genetics | Vascular Medicine | Research Article | Anatomy | Mathematics | Kidneys | Mathematical and Statistical Techniques | Genetic Loci | Population Groupings | QH426-470 | Genetics | Physical Sciences | People and Places | Genome Analysis | Genomics | Blood Pressure | Statistics (Mathematics) | Biology and Life Sciences | Research and Analysis Methods | Meta-Analysis | Ethnicities | Mammalian Genomics | Africans | Animal Genomics | Medicine and Health Sciences | Renal System | Hypertension | Genome-Wide Association Studies | Gene Expression | Statistical Methods

© 2017 Public Library of Science. All Rights Reserved. Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresen... View more