publication . Article . 2019

Multi-study validation of data-driven disease progression models to characterize evolution of biomarkers in Alzheimer's disease.

Damiano Archetti; Silvia Ingala; Vikram Venkatraghavan; Viktor Wottschel; Alexandra L. Young; Maura Bellio; Esther E. Bron; Stefan Klein; Frederik Barkhof; Daniel C. Alexander; ...
Open Access English
  • Published: 01 Jul 2019
Abstract
Understanding the sequence of biological and clinical events along the course of Alzheimer's disease provides insights into dementia pathophysiology and can help participant selection in clinical trials. Our objective is to train two data-driven computational models for sequencing these events, the Event Based Model (EBM) and discriminative-EBM (DEBM), on the basis of well-characterized research data, then validate the trained models on subjects from clinical cohorts characterized by less-structured data-acquisition protocols. Seven independent data cohorts were considered totalling 2389 cognitively normal (CN), 1424 mild cognitive impairment (MCI) and 743 Alzhe...
Subjects
free text keywords: Alzheimer's disease, biomarkers progression, event-based models, inter-cohort validation, patient staging, Alzheimer's disease, Biomarkers progression, Event-based models, Inter-cohort validation, Patient staging, yes, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429, Regular Article, Aβ1–42, Amyloid-β 1,42, AD, Alzheimer's disease, ADAS-Cog, Alzheimer's Disease Assessment Scale – Cognitive, ADC, Amsterdam Dementia Cohort, ADNI, Alzheimer's Disease Neuroimaging Initiative, APOE4, Apolipoprotein E ε4, ARWiBo, Alzheimer's disease Repository Without Borders, AUC, area under curve, CN, cognitively normal, CSF, cerebrospinal fluid, DEBM, discriminative event-based model, EBM, event-based model, EDSD, European DTI Study on Dementia, ELISA, Enzyme Linked Immunosorbent Assay, eTIV, Estimated Total Intracranial Volume, GMM, Gaussian Mixture Model, MCI, Mild Cognitive Impairment, MCMC, Markov Chain Monte Carlo, MMSE, Mini Mental State Examination, MRI, Magnetic Resonance Imaging, OASIS, Open Access Series of Imaging Studies, p-Tau, phosphorylated Tau, RAVLT, Rey's Auditory Verbal Learning Test, ROC, receiver operating characteristic, SMC, subjective memory complaint, SuStaIn, Subtype and Stage Inference, t-Tau, total Tau, ViTA, Vienna Transdanube Aging, Cognitive Neuroscience, Radiology Nuclear Medicine and imaging, Neurology, Clinical Neurology, Disease, Biomarker (medicine), Test set, Oncology, medicine.medical_specialty, medicine, Dementia, medicine.disease, Clinical trial, Stage (cooking), Cognition, Neuroimaging, Internal medicine, business.industry, business, ddc:618.97
Funded by
EC| EPAD
Project
EPAD
European Prevention of Alzheimer’s Dementia Consortium
  • Funder: European Commission (EC)
  • Project Code: 115736
  • Funding stream: FP7 | SP1 | SP1-JTI
,
NIH| MORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORK
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U24RR021382-04
  • Funding stream: NATIONAL CENTER FOR RESEARCH RESOURCES
,
EC| AMYPAD
Project
AMYPAD
Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952
  • Funder: European Commission (EC)
  • Project Code: 115952
  • Funding stream: H2020 | IMI2-RIA
,
NIH| STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIA
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P50MH071616-05
  • Funding stream: NATIONAL INSTITUTE OF MENTAL HEALTH
,
NIH| Functional-anatomic exploration of cognitive control
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AG021910-05
  • Funding stream: NATIONAL INSTITUTE ON AGING
Communities
Neuroinformatics
62 references, page 1 of 5

Aisen, P.S., Petersen, R.C., Donohue, M.C., Gamst, A., Raman, R.. Alzheimer's Disease Neuroimaging Initiative. Clinical Core of the Alzheimer's disease neuroimaging initiative: progress and plans. Alzheimers Dement.. 2010; 6 (3): 239-246 [OpenAIRE] [PubMed]

Albert, M.S., DeKosky, S.T., Dickinson, D., Dubois, B., Feldman, H.H.. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement.. 2011; 7 (3): 270-279 [OpenAIRE] [PubMed]

Beekly, D.L., Ramos, E.M., Lee, W.W., Deitrich, W.D., Jacka, M.E.. NIA Alzheimer's Disease Centers. The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set. Alzheimer Dis. Assoc. Disord.. 2007; 21 (3): 249-258 [PubMed]

Bennett, D.A., Schneider, J.A., Arvanitakis, Z., Wilson, R.S.. Overview and findings from the religious orders study. Curr. Alzheimer Res.. 2012; 9 (6): 628-645 [OpenAIRE] [PubMed]

Bennett, D.A., Schneider, J.A., Buchman, A.S., Barnes, L.L., Boyle, P.A., Wilson, R.S.. Overview and findings from the rush Memory and Aging Project. Curr. Alzheimer Res.. 2012; 9 (6): 646-663 [OpenAIRE] [PubMed]

Blennow, K., Hampel, H.. CSF markers for incipient Alzheimer's disease. Lancet Neurol.. 2003; 2 (10): 605-613 [PubMed]

Blennow, K., Hampel, H., Weiner, M., Zetterberg, H.. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat. Rev. Neurol.. 2010; 6 (3): 131-144 [PubMed]

Bloom, G.S.. Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. Jama Neurol. 2014; 71 (4): 505-508 [PubMed]

Bombois, S., Duhamel, A., Salleron, J., Deramecourt, V., Mackowiack, M.A.. A new decision tree combining abeta 1–42 and p-tau levels in Alzheimer's diagnosis. Curr. Alzheimer Res.. 2013; 10 (4)

Braak, H., Braak, E.. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol.. 1991; 82 (4): 239-259 [PubMed]

Braak, H., Braak, E., Bohl, J.. Staging of Alzheimer-related cortical destruction. Eur.Neurol. 1993; 33 (6): 403-408 [OpenAIRE] [PubMed]

Brueggen K Grothe, M.J., Dyrba, M., Fellguiebel, A., Fischer, F.. The European dti study on dementia – a multicenter DTI and MRI study on Alzheimer's disease and mild cognitive impairment. Neuroimage. 2017; 144 (Pt B): 305-308 [OpenAIRE] [PubMed]

Butler, J.E.. Enzyme-linked immunosorbent assay. J. Immunoass.. 2000; 21 (2–3): 165-209

DeLong, E.M., Delong, D.M., Clarke-Pearson, D.. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988; 44 (3): 837-845 [OpenAIRE] [PubMed]

Donohue, M.C., Jacqmin-Gadda, H., Le Goff, M., Thomas, R.G., Raman, R.. Estimating long-term multivariate progression from short-term data. Alzheimers Dement.. 2014; 10 (5 Suppl): S400-S410 [OpenAIRE] [PubMed]

62 references, page 1 of 5
Abstract
Understanding the sequence of biological and clinical events along the course of Alzheimer's disease provides insights into dementia pathophysiology and can help participant selection in clinical trials. Our objective is to train two data-driven computational models for sequencing these events, the Event Based Model (EBM) and discriminative-EBM (DEBM), on the basis of well-characterized research data, then validate the trained models on subjects from clinical cohorts characterized by less-structured data-acquisition protocols. Seven independent data cohorts were considered totalling 2389 cognitively normal (CN), 1424 mild cognitive impairment (MCI) and 743 Alzhe...
Subjects
free text keywords: Alzheimer's disease, biomarkers progression, event-based models, inter-cohort validation, patient staging, Alzheimer's disease, Biomarkers progression, Event-based models, Inter-cohort validation, Patient staging, yes, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429, Regular Article, Aβ1–42, Amyloid-β 1,42, AD, Alzheimer's disease, ADAS-Cog, Alzheimer's Disease Assessment Scale – Cognitive, ADC, Amsterdam Dementia Cohort, ADNI, Alzheimer's Disease Neuroimaging Initiative, APOE4, Apolipoprotein E ε4, ARWiBo, Alzheimer's disease Repository Without Borders, AUC, area under curve, CN, cognitively normal, CSF, cerebrospinal fluid, DEBM, discriminative event-based model, EBM, event-based model, EDSD, European DTI Study on Dementia, ELISA, Enzyme Linked Immunosorbent Assay, eTIV, Estimated Total Intracranial Volume, GMM, Gaussian Mixture Model, MCI, Mild Cognitive Impairment, MCMC, Markov Chain Monte Carlo, MMSE, Mini Mental State Examination, MRI, Magnetic Resonance Imaging, OASIS, Open Access Series of Imaging Studies, p-Tau, phosphorylated Tau, RAVLT, Rey's Auditory Verbal Learning Test, ROC, receiver operating characteristic, SMC, subjective memory complaint, SuStaIn, Subtype and Stage Inference, t-Tau, total Tau, ViTA, Vienna Transdanube Aging, Cognitive Neuroscience, Radiology Nuclear Medicine and imaging, Neurology, Clinical Neurology, Disease, Biomarker (medicine), Test set, Oncology, medicine.medical_specialty, medicine, Dementia, medicine.disease, Clinical trial, Stage (cooking), Cognition, Neuroimaging, Internal medicine, business.industry, business, ddc:618.97
Funded by
EC| EPAD
Project
EPAD
European Prevention of Alzheimer’s Dementia Consortium
  • Funder: European Commission (EC)
  • Project Code: 115736
  • Funding stream: FP7 | SP1 | SP1-JTI
,
NIH| MORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORK
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U24RR021382-04
  • Funding stream: NATIONAL CENTER FOR RESEARCH RESOURCES
,
EC| AMYPAD
Project
AMYPAD
Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952
  • Funder: European Commission (EC)
  • Project Code: 115952
  • Funding stream: H2020 | IMI2-RIA
,
NIH| STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIA
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P50MH071616-05
  • Funding stream: NATIONAL INSTITUTE OF MENTAL HEALTH
,
NIH| Functional-anatomic exploration of cognitive control
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AG021910-05
  • Funding stream: NATIONAL INSTITUTE ON AGING
Communities
Neuroinformatics
62 references, page 1 of 5

Aisen, P.S., Petersen, R.C., Donohue, M.C., Gamst, A., Raman, R.. Alzheimer's Disease Neuroimaging Initiative. Clinical Core of the Alzheimer's disease neuroimaging initiative: progress and plans. Alzheimers Dement.. 2010; 6 (3): 239-246 [OpenAIRE] [PubMed]

Albert, M.S., DeKosky, S.T., Dickinson, D., Dubois, B., Feldman, H.H.. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement.. 2011; 7 (3): 270-279 [OpenAIRE] [PubMed]

Beekly, D.L., Ramos, E.M., Lee, W.W., Deitrich, W.D., Jacka, M.E.. NIA Alzheimer's Disease Centers. The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set. Alzheimer Dis. Assoc. Disord.. 2007; 21 (3): 249-258 [PubMed]

Bennett, D.A., Schneider, J.A., Arvanitakis, Z., Wilson, R.S.. Overview and findings from the religious orders study. Curr. Alzheimer Res.. 2012; 9 (6): 628-645 [OpenAIRE] [PubMed]

Bennett, D.A., Schneider, J.A., Buchman, A.S., Barnes, L.L., Boyle, P.A., Wilson, R.S.. Overview and findings from the rush Memory and Aging Project. Curr. Alzheimer Res.. 2012; 9 (6): 646-663 [OpenAIRE] [PubMed]

Blennow, K., Hampel, H.. CSF markers for incipient Alzheimer's disease. Lancet Neurol.. 2003; 2 (10): 605-613 [PubMed]

Blennow, K., Hampel, H., Weiner, M., Zetterberg, H.. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat. Rev. Neurol.. 2010; 6 (3): 131-144 [PubMed]

Bloom, G.S.. Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. Jama Neurol. 2014; 71 (4): 505-508 [PubMed]

Bombois, S., Duhamel, A., Salleron, J., Deramecourt, V., Mackowiack, M.A.. A new decision tree combining abeta 1–42 and p-tau levels in Alzheimer's diagnosis. Curr. Alzheimer Res.. 2013; 10 (4)

Braak, H., Braak, E.. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol.. 1991; 82 (4): 239-259 [PubMed]

Braak, H., Braak, E., Bohl, J.. Staging of Alzheimer-related cortical destruction. Eur.Neurol. 1993; 33 (6): 403-408 [OpenAIRE] [PubMed]

Brueggen K Grothe, M.J., Dyrba, M., Fellguiebel, A., Fischer, F.. The European dti study on dementia – a multicenter DTI and MRI study on Alzheimer's disease and mild cognitive impairment. Neuroimage. 2017; 144 (Pt B): 305-308 [OpenAIRE] [PubMed]

Butler, J.E.. Enzyme-linked immunosorbent assay. J. Immunoass.. 2000; 21 (2–3): 165-209

DeLong, E.M., Delong, D.M., Clarke-Pearson, D.. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988; 44 (3): 837-845 [OpenAIRE] [PubMed]

Donohue, M.C., Jacqmin-Gadda, H., Le Goff, M., Thomas, R.G., Raman, R.. Estimating long-term multivariate progression from short-term data. Alzheimers Dement.. 2014; 10 (5 Suppl): S400-S410 [OpenAIRE] [PubMed]

62 references, page 1 of 5
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue