publication . Article . 2011

Altered Glycogen Metabolism in Cultured Astrocytes from Mice with Chronic Glutathione Deficit; Relevance for Neuroenergetics in Schizophrenia

Lavoie, S.; Allaman, I.; Petit, J.M.; Do, K.Q.; Magistretti, P.J.;
Open Access English
  • Published: 01 Jan 2011 Journal: PLoS ONE, volume 6, issue 7 (issn: 1932-6203, eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science
Abstract
Neurodegenerative and psychiatric disorders including Alzheimer's, Parkinson's or Huntington's diseases and schizophrenia have been associated with a deficit in glutathione (GSH). In particular, a polymorphism in the gene of glutamate cysteine ligase modulatory subunit (GCLM) is associated with schizophrenia. GSH is the most important intracellular antioxidant and is necessary for the removal of reactive by-products generated by the utilization of glucose for energy supply. Furthermore, glucose metabolism through the pentose phosphate pathway is a major source of NADPH, the cofactor necessary for the regeneration of reduced glutathione. This study aims at invest...
Subjects
free text keywords: Animal Models, Cellular Stress Responses, Research Article, Biology, Molecular Cell Biology, Mental Health, Medicine, Psychiatry, Schizophrenia, Anatomy and Physiology, Q, Mouse, R, Model Organisms, Science, Physiological Processes, Energy Metabolism
81 references, page 1 of 6

Jou, MJ. Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes.. Adv Drug Deliv Rev. 2008; 60: 1512-1526 [PubMed]

Halliwell, B, Chirico, C. Lipid peroxidation: its mechanism, measurement, and significance.. American Journal of Clinical Nutrition. 1993; 57: 715S-724S [PubMed]

Halliwell, B. Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition.. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 1999; 443: 37-52

Magistretti, PJ, Squire, LBD, Bloom, Fe, du Lac, S, Ghosh, A, Spitzer, N. Brain Energy Metabolism.. Fundamental Neuroscience, 3rd Edition. 2008: 271-293

Dringen, R. Metabolism and functions of glutathione in brain.. Progress in Neurobiology. 2000; 62: 649-671 [PubMed]

Orlowski, M, Karkowsky, A. Glutathione metabolism and some possible functions of glutathione in the nervous system.. Int Rev Neurobiol. 1976; 19: 75-121 [PubMed]

Meister, A, Anderson, ME. Glutathione.. Annual Review of Biochemistry. 1983; 52: 711-760 [OpenAIRE]

Hammond, CL, Lee, TK, Ballatori, N. Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes.. J Hepatol. 2001; 34: 946-954 [PubMed]

Ursini, MV, Parrella, A, Rosa, G, Salzano, S, Martini, G. Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress.. Biochem J. 1997; 323: 801-806 [OpenAIRE] [PubMed]

Garcia-Nogales, P, Almeida, A, Bolanos, JP. Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection.. Journal of Biological Chemistry. 2003; 278: 864-874 [PubMed]

Rui, B, Shen, T, Zhou, H, Liu, J, Chen, J. A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress.. BMC Syst Biol. 2010; 4: 122 [OpenAIRE] [PubMed]

Kussmaul, L, Hamprecht, B, Dringen, R. The Detoxification of Cumene Hydroperoxide by the Glutathione System of Cultured Astroglial Cells Hinges on Hexose Availability for the Regeneration of NADPH.. Journal of Neurochemistry. 1999; 73: 1246-1253 [PubMed]

Dringen, R, Hamprecht, B. Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells.. Brain Research. 1997; 759: 67-75 [PubMed]

Pias, EK, Aw, TY. Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production.. The FASEB Journal. 2002; 16: 781-790 [PubMed]

Dringen, R, Hirrlinger, J. Glutathione pathways in the brain.. Biol Chem. 2003; 384: 505-516 [PubMed]

81 references, page 1 of 6
Abstract
Neurodegenerative and psychiatric disorders including Alzheimer's, Parkinson's or Huntington's diseases and schizophrenia have been associated with a deficit in glutathione (GSH). In particular, a polymorphism in the gene of glutamate cysteine ligase modulatory subunit (GCLM) is associated with schizophrenia. GSH is the most important intracellular antioxidant and is necessary for the removal of reactive by-products generated by the utilization of glucose for energy supply. Furthermore, glucose metabolism through the pentose phosphate pathway is a major source of NADPH, the cofactor necessary for the regeneration of reduced glutathione. This study aims at invest...
Subjects
free text keywords: Animal Models, Cellular Stress Responses, Research Article, Biology, Molecular Cell Biology, Mental Health, Medicine, Psychiatry, Schizophrenia, Anatomy and Physiology, Q, Mouse, R, Model Organisms, Science, Physiological Processes, Energy Metabolism
81 references, page 1 of 6

Jou, MJ. Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes.. Adv Drug Deliv Rev. 2008; 60: 1512-1526 [PubMed]

Halliwell, B, Chirico, C. Lipid peroxidation: its mechanism, measurement, and significance.. American Journal of Clinical Nutrition. 1993; 57: 715S-724S [PubMed]

Halliwell, B. Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition.. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 1999; 443: 37-52

Magistretti, PJ, Squire, LBD, Bloom, Fe, du Lac, S, Ghosh, A, Spitzer, N. Brain Energy Metabolism.. Fundamental Neuroscience, 3rd Edition. 2008: 271-293

Dringen, R. Metabolism and functions of glutathione in brain.. Progress in Neurobiology. 2000; 62: 649-671 [PubMed]

Orlowski, M, Karkowsky, A. Glutathione metabolism and some possible functions of glutathione in the nervous system.. Int Rev Neurobiol. 1976; 19: 75-121 [PubMed]

Meister, A, Anderson, ME. Glutathione.. Annual Review of Biochemistry. 1983; 52: 711-760 [OpenAIRE]

Hammond, CL, Lee, TK, Ballatori, N. Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes.. J Hepatol. 2001; 34: 946-954 [PubMed]

Ursini, MV, Parrella, A, Rosa, G, Salzano, S, Martini, G. Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress.. Biochem J. 1997; 323: 801-806 [OpenAIRE] [PubMed]

Garcia-Nogales, P, Almeida, A, Bolanos, JP. Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection.. Journal of Biological Chemistry. 2003; 278: 864-874 [PubMed]

Rui, B, Shen, T, Zhou, H, Liu, J, Chen, J. A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress.. BMC Syst Biol. 2010; 4: 122 [OpenAIRE] [PubMed]

Kussmaul, L, Hamprecht, B, Dringen, R. The Detoxification of Cumene Hydroperoxide by the Glutathione System of Cultured Astroglial Cells Hinges on Hexose Availability for the Regeneration of NADPH.. Journal of Neurochemistry. 1999; 73: 1246-1253 [PubMed]

Dringen, R, Hamprecht, B. Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells.. Brain Research. 1997; 759: 67-75 [PubMed]

Pias, EK, Aw, TY. Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production.. The FASEB Journal. 2002; 16: 781-790 [PubMed]

Dringen, R, Hirrlinger, J. Glutathione pathways in the brain.. Biol Chem. 2003; 384: 505-516 [PubMed]

81 references, page 1 of 6
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publication . Article . 2011

Altered Glycogen Metabolism in Cultured Astrocytes from Mice with Chronic Glutathione Deficit; Relevance for Neuroenergetics in Schizophrenia

Lavoie, S.; Allaman, I.; Petit, J.M.; Do, K.Q.; Magistretti, P.J.;