The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis

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Lamana, Amalia; Balsa, Alejandro; Rueda Medina, Blanca; Ortiz, Ana M.; Nuño, Laura; Miranda-Carus, María Eugenia; González-Escribano, María F.; López Nevot, Miguel Ángel; Pascual Salcedo, Dora; Martín Ibáñez, Javier; González-Álvaro, Isidoro;
  • Publisher: Public Library of Science
  • Journal: volume 7,issue 8issn: 1932-6203, eissn: 1932-6203
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0043661, pmc: PMC3427144, handle: 10261/86310
  • Subject: Genetics of the Immune System | Human genetics | Research Article | Variant genotypes | Rheumatology | Polymorphism | HLA-DRB1 Chains | Genetics | Observational Studies | Alleles | Autoimmune Diseases | Population Genetics | Genetics of disease | Biology | STAT4 Transcription Factor | Medicina | Clinical Research Design | Medicine | Rheumatoid Arthritis | Personalized Medicine | Q | Disabilities | R | Arthritis | Clinical Immunology | Clinical Genetics | Science | Genetic Polymorphism | Longitudinal Studies

Background: The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we investigated the... View more
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