Low Levels of IgG Recognizing the α-1-Antitrypsin Peptide and Its Association with Taiwanese Women with Primary Sjögren’s Syndrome

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Yu-Sheng Chang; Chih-Hong Pan; Che-Chang Chang; Kai-Leun Tsai; Han-Wen Chou; Jin-Hua Chen; Sheng-Hong Lin; Yi-Ying Lu; Chih-Chun Tai; Yi-Fang Lin; Ching-Yu Lin;
  • Publisher: MDPI AG
  • Journal: International Journal of Molecular Sciences,volume 18,issue 12 (issn: 1422-0067, eissn: 1422-0067)
  • Related identifiers: pmc: PMC5751349, doi: 10.3390/ijms18122750
  • Subject: Chemistry | α-1-antitrypsin | primary Sjögren’s syndrome | inhibitor | QD1-999 | autoantibody isotypes | serum | 4-hydroxy-2-nonenal | Article | Biology (General) | QH301-705.5

The aim of this study was to examine oxidative stress and low level of α-1-antitrypsin (A1AT) in primary Sjögren’s syndrome (pSS), and evaluate the associated autoreactivity against unmodified and their 4-hydroxy-2-nonenal (HNE)-modified peptides with pSS. Two different... View more
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