New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate

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Cui, Jihong; Hollmén, Maija; Li, Lina; Chen, Yong; Proulx, Steven T.; Reker, Daniel; Schneider, Gisbert; Detmar, Michael;
  • Publisher: Impact Journals LLC
  • Journal: Oncotarget,volume 8,issue 1,pages1,007-1,022 (eissn: 1949-2553)
  • Related identifiers: pmc: PMC5352030, doi: 10.18632/oncotarget.13537, doi: 10.3929/ethz-b-000207533
  • Subject: benztropine mesylate | Prestwick library; NCI DTP-diversity set II; cell-based phenotypic screening; benztropine mesylate; breast cancer stem cells | cell-based phenotypic screening | breast cancer stem cells | Research Paper | NCI DTP-diversity set II | Prestwick library

Cancer stem cells (CSCs) play major roles in cancer initiation, metastasis, recurrence and therapeutic resistance. Targeting CSCs represents a promising strategy for cancer treatment. The purpose of this study was to identify selective inhibitors of breast CSCs (BCSCs).... View more
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