Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

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Harada, Akihiro; Okada, Tetsuya; Sato, Takashi; Mori, Kazutoshi; Yamamoto, Keisuke; Takahara, Kazuna; Oyadomari, Seiichi;
(2010)
  • Publisher: The American Society for Cell Biology
  • Journal: Molecular Biology of the Cell,volume 21,issue 17,pages2,975-2,986 (issn: 1059-1524, eissn: 1939-4586)
  • Related identifiers: pmc: PMC2929991, doi: 10.1091/mbc.E09-02-0133
  • Subject: Articles | Biosynthesis & Biodegradation

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates homeostatic responses collectively termed the unfolded protein response. Among the three principal signaling pathways operating in mammals, activating transcription factor (ATF)6α plays a pivo... View more
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