Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes

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Wang, Xin; Hao, Limin; Saur, Taixiang; Joyal, Katelyn; Zhao, Ying; Zhai, Desheng; Li, Jie; Pribadi, Mochtar; Coppola, Giovanni; Cohen, Bruce M.; Buttner, Edgar A.;

An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF... View more