Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related PhenotypesArticle English OPEN
Wang, Xin; Hao, Limin; Saur, Taixiang; Joyal, Katelyn; Zhao, Ying; Zhai, Desheng; Li, Jie; Pribadi, Mochtar; Coppola, Giovanni; Cohen, Bruce M.; Buttner, Edgar A.; (2016)
- Publisher: Frontiers Media S.A.
- Journal: volume 9issn: 1662-5099, eissn: 1662-5099
- Related identifiers: , ,
Subject: ALS-FTLD | Neuroscience | C9ORF72 | ACP2 | Original Research | Caenorhabditis elegans | VAPB | amyotrophic lateral sclerosis An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF... View more