publication . Article . 2015

Major Factors Affecting Incidence of Childhood Thyroid Cancer in Belarus after the Chernobyl Accident: Do Nitrates in Drinking Water Play a Role?

Drozd, Valentina M.; Saenko, Vladimir A.; Brenner, Alina V.; Drozdovitch, Vladimir; Pashkevich, Vasilii I.; Kudelsky, Anatoliy V.; Demidchik, Yuri E.; Branovan, Igor; Shiglik, Nikolay; Rogounovitch, Tatiana I.; ...
Open Access English
  • Published: 23 Sep 2015 Journal: PLOS ONE, volume 10, issue 9, page e0137226 (issn: 1932-6203, eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science
Abstract
One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident. However, there remains limited understanding of factors that modify the 131I-related risk. Focusing on post-Chernobyl pediatric thyroid cancer in Belarus, we reviewed evidence of the effects of radiation, thyroid screening, and iodine deficiency on regional differences in incidence rates of thyroid canc...
Subjects
mesheuropmc: endocrine system
free text keywords: Q, R, Research Article, Science, Medicine
65 references, page 1 of 5

1 Brenner AV, Tronko MD, Hatch M, Bogdanova TI, Oliynik VA, Lubin JH, et al I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident. Environ Health Perspect. 2011;119(7):933–9. doi: 10.1289/ehp.1002674 ; PubMed Central PMCID: PMC3222994.21406336 [OpenAIRE] [PubMed]

2 Cardis E, Kesminiene A, Ivanov V, Malakhova I, Shibata Y, Khrouch V, et al Risk of thyroid cancer after exposure to 131I in childhood. J Natl Cancer Inst. 2005;97(10):724–32. doi: 10.1093/jnci/dji129 .15900042 [PubMed]

3 Dav is S, Stepanenko V, Rivkind N, Kopecky KJ, Voilleque P, Shakhtarin V, et al Risk of thyroid cancer in the Bryansk Oblast of the Russian Federation after the Chernobyl Power Station accident. Radiat Res. 2004;162(3):241–8. doi: 10.1667/RR3233 .15332999 [PubMed]

4 Ivanov VK, Kashcheev VV, Chekin SY, Maksioutov MA, Tumanov KA, Vlasov OK, et al Radiation-epidemiological studies of thyroid cancer incidence in Russia after the Chernobyl accident (estimation of radiation risks, 1991–2008 follow-up period). Radiat Prot Dosimetry. 2012;151(3):489–99. doi: 10.1093/rpd/ncs019 .22416255 [PubMed]

5 Jacob P, Kenigsberg Y, Zvonova I, Goulko G, Buglova E, Heidenreich WF, et al Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia. Br J Cancer. 1999;80(9):1461–9. doi: 10.1038/sj.bjc.6690545 ; PubMed Central PMCID: PMC2363070.10424752 [OpenAIRE] [PubMed]

6 Jacob P, Bogdanova TI, Buglova E, Chepurniy M, Demidchik Y, Gavrilin Y, et al Thyroid cancer risk in areas of Ukraine and Belarus affected by the Chernobyl accident. Radiat Res. 2006;165(1):1–8. pii: RR3479. .16392956 [PubMed]

7 Likhtarov I, Kovgan L, Vavilov S, Chepurny M, Ron E, Lubin J, et al Post-Chernobyl thyroid cancers in Ukraine. Report 2: risk analysis. Radiat Res. 2006;166(2):375–86. doi: 10.1667/RR3593.1 .16881739 [PubMed]

8 Tronko MD, Howe GR, Bogdanova TI, Bouville AC, Epstein OV, Brill AB, et al A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening. J Natl Cancer Inst. 2006;98(13):897–903. doi: 10.1093/jnci/djj244 .16818853 [PubMed]

9 Zablotska LB, Ron E, Rozhko AV, Hatch M, Polyanskaya ON, Brenner AV, et al Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident. Br J Cancer. 2011;104(1):181–7. doi: 10.1038/sj.bjc.6605967 ; PubMed Central PMCID: PMC3039791.21102590 [OpenAIRE] [PubMed]

10 Shakhtarin VV, Tsyb AF, Stepanenko VF, Orlov MY, Kopecky KJ, Davis S. Iodine deficiency, radiation dose, and the risk of thyroid cancer among children and adolescents in the Bryansk region of Russia following the Chernobyl power station accident. Int J Epidemiol. 2003;32(4):584–91. .12913034 [PubMed]

11 Shevchuk VE, Gurachevsky VL. Twenty Years after the Chernobyl Catastrophe: the consequences in the Republic of Belarus and their overcoming. National report. Minsk: Committee on the Problems of the Consequences of the Catastrophe at the Chernobyl NPP under the Belarusian Council of Ministers; 2006.

12 Ron E, Modan B, Preston D, Alfandary E, Stovall M, Boice JD Jr.Thyroid neoplasia following low-dose radiation in childhood. Radiat Res. 1989;120(3):516–31. .2594972 [PubMed]

13 Shore RE, Woodard E, Hildreth N, Dvoretsky P, Hempelmann L, Pasternack B. Thyroid tumors following thymus irradiation. J Natl Cancer Inst. 1985;74(6):1177–84. .3858590 [PubMed]

14 Favus MJ, Schneider AB, Stachura ME, Arnold JE, Ryo UY, Pinsky SM, et al Thyroid cancer occurring as a late consequence of head-and-neck irradiation. Evaluation of 1056 patients. N Engl J Med. 1976;294(19):1019–25. doi: 10.1056/NEJM197605062941901 .1256510 [PubMed]

15 Socolow EL, Hashizume A, Neriishi S, Niitani R. Thyroid carcinoma in man after exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki. N Engl J Med. 1963;268:406–10. doi: 10.1056/NEJM196302212680803 .13989805 [PubMed]

65 references, page 1 of 5
Abstract
One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident. However, there remains limited understanding of factors that modify the 131I-related risk. Focusing on post-Chernobyl pediatric thyroid cancer in Belarus, we reviewed evidence of the effects of radiation, thyroid screening, and iodine deficiency on regional differences in incidence rates of thyroid canc...
Subjects
mesheuropmc: endocrine system
free text keywords: Q, R, Research Article, Science, Medicine
65 references, page 1 of 5

1 Brenner AV, Tronko MD, Hatch M, Bogdanova TI, Oliynik VA, Lubin JH, et al I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident. Environ Health Perspect. 2011;119(7):933–9. doi: 10.1289/ehp.1002674 ; PubMed Central PMCID: PMC3222994.21406336 [OpenAIRE] [PubMed]

2 Cardis E, Kesminiene A, Ivanov V, Malakhova I, Shibata Y, Khrouch V, et al Risk of thyroid cancer after exposure to 131I in childhood. J Natl Cancer Inst. 2005;97(10):724–32. doi: 10.1093/jnci/dji129 .15900042 [PubMed]

3 Dav is S, Stepanenko V, Rivkind N, Kopecky KJ, Voilleque P, Shakhtarin V, et al Risk of thyroid cancer in the Bryansk Oblast of the Russian Federation after the Chernobyl Power Station accident. Radiat Res. 2004;162(3):241–8. doi: 10.1667/RR3233 .15332999 [PubMed]

4 Ivanov VK, Kashcheev VV, Chekin SY, Maksioutov MA, Tumanov KA, Vlasov OK, et al Radiation-epidemiological studies of thyroid cancer incidence in Russia after the Chernobyl accident (estimation of radiation risks, 1991–2008 follow-up period). Radiat Prot Dosimetry. 2012;151(3):489–99. doi: 10.1093/rpd/ncs019 .22416255 [PubMed]

5 Jacob P, Kenigsberg Y, Zvonova I, Goulko G, Buglova E, Heidenreich WF, et al Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia. Br J Cancer. 1999;80(9):1461–9. doi: 10.1038/sj.bjc.6690545 ; PubMed Central PMCID: PMC2363070.10424752 [OpenAIRE] [PubMed]

6 Jacob P, Bogdanova TI, Buglova E, Chepurniy M, Demidchik Y, Gavrilin Y, et al Thyroid cancer risk in areas of Ukraine and Belarus affected by the Chernobyl accident. Radiat Res. 2006;165(1):1–8. pii: RR3479. .16392956 [PubMed]

7 Likhtarov I, Kovgan L, Vavilov S, Chepurny M, Ron E, Lubin J, et al Post-Chernobyl thyroid cancers in Ukraine. Report 2: risk analysis. Radiat Res. 2006;166(2):375–86. doi: 10.1667/RR3593.1 .16881739 [PubMed]

8 Tronko MD, Howe GR, Bogdanova TI, Bouville AC, Epstein OV, Brill AB, et al A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening. J Natl Cancer Inst. 2006;98(13):897–903. doi: 10.1093/jnci/djj244 .16818853 [PubMed]

9 Zablotska LB, Ron E, Rozhko AV, Hatch M, Polyanskaya ON, Brenner AV, et al Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident. Br J Cancer. 2011;104(1):181–7. doi: 10.1038/sj.bjc.6605967 ; PubMed Central PMCID: PMC3039791.21102590 [OpenAIRE] [PubMed]

10 Shakhtarin VV, Tsyb AF, Stepanenko VF, Orlov MY, Kopecky KJ, Davis S. Iodine deficiency, radiation dose, and the risk of thyroid cancer among children and adolescents in the Bryansk region of Russia following the Chernobyl power station accident. Int J Epidemiol. 2003;32(4):584–91. .12913034 [PubMed]

11 Shevchuk VE, Gurachevsky VL. Twenty Years after the Chernobyl Catastrophe: the consequences in the Republic of Belarus and their overcoming. National report. Minsk: Committee on the Problems of the Consequences of the Catastrophe at the Chernobyl NPP under the Belarusian Council of Ministers; 2006.

12 Ron E, Modan B, Preston D, Alfandary E, Stovall M, Boice JD Jr.Thyroid neoplasia following low-dose radiation in childhood. Radiat Res. 1989;120(3):516–31. .2594972 [PubMed]

13 Shore RE, Woodard E, Hildreth N, Dvoretsky P, Hempelmann L, Pasternack B. Thyroid tumors following thymus irradiation. J Natl Cancer Inst. 1985;74(6):1177–84. .3858590 [PubMed]

14 Favus MJ, Schneider AB, Stachura ME, Arnold JE, Ryo UY, Pinsky SM, et al Thyroid cancer occurring as a late consequence of head-and-neck irradiation. Evaluation of 1056 patients. N Engl J Med. 1976;294(19):1019–25. doi: 10.1056/NEJM197605062941901 .1256510 [PubMed]

15 Socolow EL, Hashizume A, Neriishi S, Niitani R. Thyroid carcinoma in man after exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki. N Engl J Med. 1963;268:406–10. doi: 10.1056/NEJM196302212680803 .13989805 [PubMed]

65 references, page 1 of 5
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publication . Article . 2015

Major Factors Affecting Incidence of Childhood Thyroid Cancer in Belarus after the Chernobyl Accident: Do Nitrates in Drinking Water Play a Role?

Drozd, Valentina M.; Saenko, Vladimir A.; Brenner, Alina V.; Drozdovitch, Vladimir; Pashkevich, Vasilii I.; Kudelsky, Anatoliy V.; Demidchik, Yuri E.; Branovan, Igor; Shiglik, Nikolay; Rogounovitch, Tatiana I.; ...