Cellular promyelocytic leukemia protein is an important dengue virus restriction factor.

Article English OPEN
Federico Giovannoni; Elsa B Damonte; Cybele C García;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 10,issue 5 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC4427460, doi: 10.1371/journal.pone.0125690
  • Subject: Q | R | Research Article | Ciencias Biológicas | Virología | dengue virus | Science | Medicine | PML | Host restriction factor | CIENCIAS NATURALES Y EXACTAS

The intrinsic antiviral defense is based on cellular restriction factors that are constitutively expressed and, thus, active even before a pathogen enters the cell. The promyelocytic leukemia (PML) nuclear bodies (NBs) are discrete nuclear foci that contain several cell... View more