Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity

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Latif-Hernandez, Amira; Shah, Disha; Ahmed, Tariq; Lo, Adrian C.; Callaerts-Vegh, Zsuzsanna; Van Der Linden, Anne-Marie; Balschun, Detlef; D'Hooge, Rudi;
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC5098239, doi: 10.1038/srep36489
  • Subject: Animals; Female; Hippocampus/drug effects; Hippocampus/metabolism; Long-Term Potentiation/drug effects; Magnetic Resonance Imaging/methods; Maze Learning/drug effects; Mice; Mice, Inbred C57BL; Neuronal Plasticity/drug effects; Neurons/drug effects; Neurons/metabolism; Prefrontal Cortex/drug effects; Prefrontal Cortex/metabolism; Quinolinic Acid/pharmacology; Receptors, N-Methyl-D-Aspartate/metabolism; Reversal Learning/drug effects | Engineering sciences. Technology | Article
    mesheuropmc: nervous system | psychological phenomena and processes

Abstract: Intracerebral injection of the excitotoxic, endogenous tryptophan metabolite, quinolinic acid (QA), constitutes a chemical model of neurodegenerative brain disease. Complementary techniques were combined to examine the consequences of QA injection into medial ... View more
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