Facilitated dissociation of transcription factors from single DNA binding sites

Preprint, Other literature type English OPEN
De La Cruz, Monica; Erbas, Aykut; Banigan, Ed; Kamar, Ramsey; Marko, John; Johnson, Reid; Giuntoli, Rebecca;

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits TF off-rates are independent of TF concentration in s... View more
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