Small Molecular TRAIL Inducer ONC201 Induces Death in Lung Cancer Cells: A Preclinical Study

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Yuan Feng; Jihong Zhou; Zhanhua Li; Ying Jiang; Ying Zhou;
(2016)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 11,issue 9 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0162133, pmc: PMC5023178
  • Subject: Cancer Treatment | Research Article | Anatomy | Pathology and Laboratory Medicine | Apoptosis | Colorimetric assays | Oncology | Cell Processes | Bioassays and physiological analysis | Genetics | Biological Tissue | Lung and Intrathoracic Tumors | Cancers and Neoplasms | Cytotoxicity | MTT assay | Toxicology | Non-Small Cell Lung Cancer | Cellular Types | Biology and Life Sciences | Non-coding RNA | Cell Death | RNA | Research and analysis methods | Epithelial Cells | Medicine | Animal Cells | Nucleic acids | Small interfering RNAs | Q | R | Cell Biology | Gene regulation | Enzyme assays | Science | Biochemistry | Epithelium | Medicine and Health Sciences | Gene expression | Biochemical analysis
    mesheuropmc: respiratory tract diseases | respiratory system

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively targets cancer cells. The present preclinical study investigated the anti-cancer efficiency of ONC201, a first-in-class small molecule TRAIL inducer, in lung cancer cells. We showed that O... View more
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