publication . Other literature type . Article . 2019

Disproportionate Effect of Sub-Micron Topography on Osteoconductive Capability of Titanium

Saruta, Juri; Sato, Nobuaki; Ishijima, Manabu; Okubo, Takahisa; Hirota, Makoto; Ogawa, Takahiro;
Open Access English
  • Published: 01 Aug 2019 Journal: International Journal of Molecular Sciences, volume 20, issue 16 (issn: 1422-0067, eissn: 1422-0067, Copyright policy)
  • Publisher: Multidisciplinary Digital Publishing Institute
Abstract
Titanium micro-scale topography offers excellent osteoconductivity and bone−implant integration. However, the biological effects of sub-micron topography are unknown. We compared osteoblastic phenotypes and in vivo bone and implant integration abilities between titanium surfaces with micro- (1−5 µm) and sub-micro-scale (0.1−0.5 µm) compartmental structures and machined titanium. The calculated average roughness was 12.5 ± 0.65, 123 ± 6.15, and 24 ± 1.2 nm for machined, micro-rough, and sub-micro-rough surfaces, respectively. In culture studies using bone marrow-derived osteoblasts, the micro-rough surface showed the low...
Subjects
free text keywords: Chemistry, bone integration, micro-rough, acid-etching, sub-micro-rough, QD1-999, osseointegration, orthopedic implants, Article, dental implants, QH301-705.5, bone regeneration, Biology (General)
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publication . Other literature type . Article . 2019

Disproportionate Effect of Sub-Micron Topography on Osteoconductive Capability of Titanium

Saruta, Juri; Sato, Nobuaki; Ishijima, Manabu; Okubo, Takahisa; Hirota, Makoto; Ogawa, Takahiro;