Oncogenic herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication

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Balistreri, Giuseppe; Viiliainen, Johanna; Turunen, Mikko; Diaz, Raquel; Lyly, Lauri; Pekkonen, Pirita; Rantala, Juha; Ojala, Krista; Sarek, Grzegorz; Teesalu, Mari; Denisova, Oxana; Peltonen, Karita; Julkunen, Ilkka; Varjosalo, Markku; Kainov, Denis; Kallioniemi, Olli; Laiho, Marikki; Taipale, Jussi; Hautaniemi, Sampsa; Ojala, Paivi M.;
(2016)
  • Publisher: Public Library of Science
  • Journal: PLoS Pathogens,volume 12,issue 2 (issn: 1553-7366, eissn: 1553-7374)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4758658, doi: 10.1371/journal.ppat.1005424
  • Subject: SARCOMA-ASSOCIATED HERPESVIRUS | NUCLEAR ANTIGEN | RC581-607 | Research Article | Fluorescence Imaging | DNA damage | Immunoassays | GENE-EXPRESSION | Immunologic diseases. Allergy | Image Analysis | Cell Processes | KAPOSIS-SARCOMA | 3111 Biomedicine | Genetics | DNA | HISTONE H3 PHOSPHORYLATION | DNA-DAMAGE CHECKPOINT | Immunology | Immunofluorescence | MITOTIC CHROMOSOME CONDENSATION | Biology and life sciences | Non-coding RNA | RNA | INDUCED LYMPHOMAS | Research and Analysis Methods | Microbiology | Nucleic acids | Immunologic Techniques | QH301-705.5 | Viral Replication | Small interfering RNAs | Medical Microbiology | Cell Biology | EPSTEIN-BARR-VIRUS | Imaging Techniques | Virology | Gene regulation | Biochemistry | BREAST-CANCER CELLS | Gene Expression | Biology (General) | Cell Cycle and Cell Division
    mesheuropmc: viruses

Kaposi's sarcoma herpesvirus (KSHV) causes Kaposi's sarcoma and certain lymphoproliferative malignancies. Latent infection is established in the majority of tumor cells, whereas lytic replication is reactivated in a small fraction of cells, which is important for both v... View more