Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans

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Motta, Guacyara; Tersariol, Ivarne L. S.;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Physiology,volume 8 (issn: 1664-042X, eissn: 1664-042X)
  • Related identifiers: doi: 10.3389/fphys.2017.00481/full, doi: 10.3389/fphys.2017.00481, pmc: PMC5504176
  • Subject: proteoglycans | QP1-981 | kininogen | inflammation | kallikrein | Physiology | bradykinin | Mini Review | endocytosis | proteolysis
    mesheuropmc: carbohydrates (lipids) | circulatory and respiratory physiology

Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H-kininogen. Heparan s... View more
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