PUMA: A Puzzle Piece in Chloroquine’s Antimelanoma Activity

Article English OPEN
Amaravadi, Ravi K.;
(2013)
  • Publisher: Elsevier BV
  • Journal: Journal of Investigative Dermatology,volume 133,issue 9,pages2,133-2,135 (issn: 0022-202X, eissn: 1523-1747)
  • Related identifiers: pmc: PMC4825873, doi: 10.1038/jid.2013.135
  • Subject: Molecular Biology | Cell Biology | Dermatology | Biochemistry | Article

Chloroquine can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible. While it is well known that chloroquine impairs lysosomal function and can serve as an autophagy inhibitor, the molecular target of chloroquine and th... View more
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