A systems level approach reveals new gene regulatory modules in the developing ear

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Chen, Jingchen ; Tambalo, Monica ; Barembaum, Meyer ; Ranganathan, Ramya ; Simões-Costa, Marcos ; Bronner, Marianne E. ; Streit, Andrea (2017)
  • Publisher: Company of Biologists
  • Journal: volume 144, issue 8, pages 1,531-1,543 (issn: 0950-1991, eissn: 1477-9129)
  • Related identifiers: doi: 10.1242/dev.148494, pmc: PMC5399671
  • Subject: Transcription factor | Research Article | Auditory system | Cell fate | Placode | Embryo | Hearing | Chick
    mesheuropmc: embryonic structures | sense organs | animal structures

The inner ear is a complex vertebrate sense organ, yet it arises from a simple epithelium, the otic placode. Specification towards otic fate requires diverse signals and transcriptional inputs that act sequentially and/or in parallel. Using the chick embryo, we uncover ... View more
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