Dendritic cells that phagocytose apoptotic macrophages loaded with mycobacterial antigens activate CD8 T cells via cross-presentation.

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Patricia Espinosa-Cueto ; Alejandro Magallanes-Puebla ; Carlos Castellanos ; Raul Mancilla
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 12, issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC5540487, doi: 10.1371/journal.pone.0182126
  • Subject: Research Article | Antigen Presentation | Apoptosis | Cell Processes | Spectrophotometry | Molecular Development | White blood cells | Immune System | Spectrum Analysis Techniques | Cytokines | Flow Cytometry | Immunology | Cellular types | Phagocytosis | Biology and Life Sciences | Cell Death | Immune Physiology | Developmental Biology | Research and Analysis Methods | Blood cells | Physiology | Immune cells | Animal cells | Medicine | Innate Immune System | Q | R | Cell Biology | Cytotoxic T cells | T cells | Cellular Structures and Organelles | Cell Walls | Science | Cytophotometry | Medicine and Health Sciences
    mesheuropmc: chemical and pharmacologic phenomena

While homeostatic apoptosis is immunologically silent, macrophage apoptosis during Mycobacterium tuberculosis infection can potentially induce an immune response against the mycobacteria. To examine the role of dendritic cells in this response, macrophage apoptosis was ... View more
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