The role of the leukemia-associated ETO homologue repressors in hematopoiesis

Doctoral thesis English OPEN
Olsson, André;
  • Publisher: Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University
  • Journal: issn: 1652-8220
  • Publisher copyright policies & self-archiving
  • Subject: Medicine (human and vertebrates) | ETO | leukemia | Hematologi | MTGR1 | AML1-ETO | Haematology | extracellular fluids | extracellulära vätskor | hematopoiesis | Hematology | MTG16 | diffferentiation | Medicin (människa och djur)

The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO... View more
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